Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
REACTOME PATHWAYThe Erythropoietin activates Phosphoinositide-3-kinase (PI3K) pathway (Reactome ID: R-HSA-9027276) involves 7 genes and is affected by 31 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | ly294002 | — | 11 |
| 2 | pictilisib | — | 25 |
| 3 | Wortmannin | — | 300 |
| 4 | Sirolimus | — | 300 |
| 5 | alpelisib | — | 227 |
| 6 | torin 1 | — | 10 |
| 7 | Dasatinib | — | 299 |
| 8 | Quercetin | — | 300 |
| 9 | Azauridine | — | 300 |
| 10 | Cladribine | — | 297 |
| 11 | Methylene Blue | — | 200 |
| 12 | 2-Methoxyestradiol | — | 300 |
| 13 | Astemizole Antihistamine drug now withdrawn from | — | 280 |
| 14 | Azathioprine | — | 300 |
| 15 | Calcitriol | — | 300 |
| 16 | Camptothecin | — | 300 |
| 17 | Cytarabine | — | 297 |
| 18 | dihydrorotenone | — | 13 |
| 19 | Podophyllotoxin | — | 14 |
| 20 | streptonigrin | — | 299 |
| 21 | Trifluridine | — | 295 |
| 22 | Tripterygium | — | 300 |
| 23 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 24 | Ku 0063794 [Supplementary Concept] | — | 7 |
| 25 | Sorafenib | — | 300 |
| 26 | tyrphostin ag 1478 | — | 4 |
| 27 | alsterpaullone | — | 12 |
| 28 | Crizotinib | — | 298 |
| 29 | kenpaullone | — | 8 |
| 30 | sp600125 | — | 117 |
| 31 | Resveratrol | — | 298 |
About the Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Pathway
The Erythropoietin activates Phosphoinositide-3-kinase (PI3K) pathway is catalogued in Reactome (ID: R-HSA-9027276) and involves 7 genes. In the BiohacksAI corpus, 31 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include JAK2, LYN, PIK3CB, PIK3CD, PIK3CG.