What compounds affect the HCMV Early Events pathway?

114 compounds in the BiohacksAI corpus have documented interactions with genes in the HCMV Early Events pathway (Reactome ID: R-HSA-9609690). These compounds target 26 genes within this pathway.

What genes are in the HCMV Early Events pathway?

The HCMV Early Events pathway involves 26 genes. Key genes include: CBX1, CREB1, EED, EGFR, EZH2, HDAC3, NCOR1, NCOR2, NFKB1, TUBA1A.

HCMV Early Events

REACTOME PATHWAY

Reactome: R-HSA-960969026 genes114 compounds

The HCMV Early Events pathway (Reactome ID: R-HSA-9609690) involves 26 genes and is affected by 114 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CBX1 CREB1 EED EGFR EZH2 HDAC3 NCOR1 NCOR2 NFKB1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B

Compounds Affecting HCMV Early Events

#	Compound	Targets Hit	Studies
1	Nocodazole Nocodazole is	—	215
2	Vorinostat	—	299
3	Colchicine	—	300
4	Podophyllotoxin	—	14
5	Vincristine	—	299
6	Noscapine	—	300
7	Demecolcine	—	246
8	Maytansine	—	300
9	vinblastine sulfate	—	81
10	Disulfiram	—	297
11	Bortezomib	—	300
12	Quercetin	—	300
13	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
14	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
15	Dasatinib	—	299
16	Daunorubicin	—	298
17	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
18	Nisoldipine	—	297
19	ly294002	—	11
20	tyrphostin 1	—	1
21	tyrphostin ag 1478	—	4
22	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
23	ag490	—	14
24	scriptaid	—	53
25	Biotin	—	297
26	cycloheximide	—	300
27	Azacitidine	—	298
28	Azacitidine	—	300
29	Levalbuterol	—	1,000
30	Adenosine Monophosphate Adenine nucleotide containing	—	300
31	Levalbuterol	—	297
32	Clofarabine	—	298
33	Dactinomycin	—	297
34	Danazol	—	298
35	Emetine	—	298
36	Ethidium	—	300
37	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
38	Sulbactam	—	299
39	trequinsin hydrochloride	—	1
40	chrysin	—	300
41	Genistein	—	300
42	Testosterone	—	299
43	Ciclopirox	—	88
44	Cladribine	—	297
45	Clenbuterol	—	300
46	Corticosterone	—	300
47	Dinoprostone	—	296
48	Epinephrine	—	299
49	Ethinyl Estradiol	—	300
50	Imatinib Mesylate	—	300

About the HCMV Early Events Pathway

The HCMV Early Events pathway is catalogued in Reactome (ID: R-HSA-9609690) and involves 26 genes. In the BiohacksAI corpus, 114 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CBX1, CREB1, EED, EGFR, EZH2.