FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes

Q: What compounds affect the FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes pathway?

207 compounds in the BiohacksAI corpus have documented interactions with genes in the FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes pathway (Reactome ID: R-HSA-9615017). These compounds target 10 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-961501710 genes207 compounds

The FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes pathway (Reactome ID: R-HSA-9615017) involves 10 genes and is affected by 207 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FOXO3 GCK HDAC1 HDAC2 INS NR3C1 SIRT3 SMAD2 SMAD3 SREBF1

Compounds Affecting FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes

#	Compound	Targets Hit	Studies
1	Daunorubicin	—	298
2	Celecoxib	—	295
3	Quercetin	—	300
4	Bortezomib	—	300
5	Azacitidine	—	298
6	Azacitidine	—	300
7	cycloheximide	—	300
8	Ethinyl Estradiol	—	300
9	Danazol	—	298
10	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
11	Dactinomycin	—	297
12	Vorinostat	—	299
13	Digitoxin	—	300
14	Equilin	—	216
15	Nisoldipine	—	297
16	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
17	chrysin	—	300
18	Kaempferols	—	300
19	Ciclopirox	—	88
20	Dasatinib	—	299
21	Emetine	—	298
22	Lynestrenol	—	299
23	o-Phthalaldehyde	—	300
24	Sulbactam	—	299
25	Flutamide	—	298
26	Digoxin	—	299
27	Disulfiram	—	297
28	Colchicine	—	300
29	Dinitrochlorobenzene	—	300
30	Ethidium	—	300
31	Loratadine	—	296
32	Oxyphenbutazone	—	300
33	Podophyllotoxin	—	14
34	vinblastine sulfate	—	81
35	Vincristine	—	299
36	egcg	—	300
37	Fluoxetine	—	1,000
38	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
39	Astemizole Antihistamine drug now withdrawn from	—	280
40	Cladribine	—	297
41	Domperidone	—	299
42	Ezetimibe	—	296
43	Idazoxan	—	300
44	Nocodazole Nocodazole is	—	215
45	Masoprocol	—	300
46	Perphenazine	—	297
47	pivampicillin	—	275
48	Promethazine	—	121
49	Rotenone	—	300
50	Salmeterol Xinafoate	—	227

About the FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Pathway

The FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes pathway is catalogued in Reactome (ID: R-HSA-9615017) and involves 10 genes. In the BiohacksAI corpus, 207 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FOXO3, GCK, HDAC1, HDAC2, INS.