What genes are in the FOXO-mediated transcription of cell cycle genes pathway?

The FOXO-mediated transcription of cell cycle genes pathway involves 4 genes. Key genes include: FOXO3, MSTN, SMAD2, SMAD3.

FOXO-mediated transcription of cell cycle genes

Q: What compounds affect the FOXO-mediated transcription of cell cycle genes pathway?

65 compounds in the BiohacksAI corpus have documented interactions with genes in the FOXO-mediated transcription of cell cycle genes pathway (Reactome ID: R-HSA-9617828). These compounds target 4 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-96178284 genes65 compounds

The FOXO-mediated transcription of cell cycle genes pathway (Reactome ID: R-HSA-9617828) involves 4 genes and is affected by 65 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FOXO3 MSTN SMAD2 SMAD3

Compounds Affecting FOXO-mediated transcription of cell cycle genes

#	Compound	Targets Hit	Studies
1	cycloheximide	—	300
2	Azacitidine	—	298
3	Azacitidine	—	300
4	Disulfiram	—	297
5	Nisoldipine	—	297
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Kaempferols	—	300
8	Quercetin	—	300
9	Colchicine	—	300
10	Dactinomycin	—	297
11	Danazol	—	298
12	Dasatinib	—	299
13	Dinitrochlorobenzene	—	300
14	Ethidium	—	300
15	Flutamide	—	298
16	Loratadine	—	296
17	Oxyphenbutazone	—	300
18	Podophyllotoxin	—	14
19	vinblastine sulfate	—	81
20	Vincristine	—	299
21	chrysin	—	300
22	egcg	—	300
23	Fluoxetine	—	1,000
24	Methylene Blue	—	200
25	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
26	Astemizole Antihistamine drug now withdrawn from	—	280
27	Bortezomib	—	300
28	Celecoxib	—	295
29	Ciclopirox	—	88
30	Cladribine	—	297
31	Daunorubicin	—	298
32	Domperidone	—	299
33	Emetine	—	298
34	Equilin	—	216
35	Ethinyl Estradiol	—	300
36	Ezetimibe	—	296
37	Idazoxan	—	300
38	Lynestrenol	—	299
39	Nocodazole Nocodazole is	—	215
40	Masoprocol	—	300
41	o-Phthalaldehyde	—	300
42	Perphenazine	—	297
43	pivampicillin	—	275
44	Promethazine	—	121
45	Rotenone	—	300
46	Salmeterol Xinafoate	—	227
47	Sulbactam	—	299
48	trequinsin hydrochloride	—	1
49	triflupromazine hydrochloride	—	12
50	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300

About the FOXO-mediated transcription of cell cycle genes Pathway

The FOXO-mediated transcription of cell cycle genes pathway is catalogued in Reactome (ID: R-HSA-9617828) and involves 4 genes. In the BiohacksAI corpus, 65 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FOXO3, MSTN, SMAD2, SMAD3.