Estrogen-dependent nuclear events downstream of ESR-membrane signaling

Q: What compounds affect the Estrogen-dependent nuclear events downstream of ESR-membrane signaling pathway?

71 compounds in the BiohacksAI corpus have documented interactions with genes in the Estrogen-dependent nuclear events downstream of ESR-membrane signaling pathway (Reactome ID: R-HSA-9634638). These compounds target 8 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-96346388 genes71 compounds

The Estrogen-dependent nuclear events downstream of ESR-membrane signaling pathway (Reactome ID: R-HSA-9634638) involves 8 genes and is affected by 71 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 CREB1 EGFR FOS FOXO3 MAPK1 MAPK3 XPO1

Compounds Affecting Estrogen-dependent nuclear events downstream of ESR-membrane signaling

#	Compound	Targets Hit	Studies
1	plumbagin [Supplementary Concept]	—	300
2	trequinsin hydrochloride	—	1
3	Dasatinib	—	299
4	Masoprocol	—	300
5	pd98059	—	7
6	tyrphostin ag 1478	—	4
7	alsterpaullone	—	12
8	kenpaullone	—	8
9	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
10	Sorafenib	—	300
11	trametinib	—	296
12	withaferin	—	300
13	cycloheximide	—	300
14	Disulfiram	—	297
15	Azacitidine	—	298
16	Azacitidine	—	300
17	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
18	Levalbuterol	—	1,000
19	Adenosine Monophosphate Adenine nucleotide containing	—	300
20	Levalbuterol	—	297
21	Bortezomib	—	300
22	Clofarabine	—	298
23	Dactinomycin	—	297
24	Danazol	—	298
25	Emetine	—	298
26	Ethidium	—	300
27	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
28	Sulbactam	—	299
29	chrysin	—	300
30	Genistein	—	300
31	Quercetin	—	300
32	Testosterone	—	299
33	Ciclopirox	—	88
34	Cladribine	—	297
35	Clenbuterol	—	300
36	Corticosterone	—	300
37	Daunorubicin	—	298
38	Dinoprostone	—	296
39	Epinephrine	—	299
40	Ethinyl Estradiol	—	300
41	Imatinib Mesylate	—	300
42	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
43	Nisoldipine	—	297
44	Nocodazole Nocodazole is	—	215
45	Norepinephrine Precursor of epinephrine that is secreted by	—	298
46	o-Phthalaldehyde	—	300
47	Oxyphenbutazone	—	300
48	pivampicillin	—	275
49	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
50	Salmeterol Xinafoate	—	227

About the Estrogen-dependent nuclear events downstream of ESR-membrane signaling Pathway

The Estrogen-dependent nuclear events downstream of ESR-membrane signaling pathway is catalogued in Reactome (ID: R-HSA-9634638) and involves 8 genes. In the BiohacksAI corpus, 71 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, CREB1, EGFR, FOS, FOXO3.