What compounds affect the Amino acids regulate mTORC1 pathway?

28 compounds in the BiohacksAI corpus have documented interactions with genes in the Amino acids regulate mTORC1 pathway (Reactome ID: R-HSA-9639288). These compounds target 4 genes within this pathway.

What genes are in the Amino acids regulate mTORC1 pathway?

The Amino acids regulate mTORC1 pathway involves 4 genes. Key genes include: ATP6V1B2, MLST8, MTOR, RPTOR.

Amino acids regulate mTORC1

REACTOME PATHWAY

Reactome: R-HSA-96392884 genes28 compounds

The Amino acids regulate mTORC1 pathway (Reactome ID: R-HSA-9639288) involves 4 genes and is affected by 28 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATP6V1B2 MLST8 MTOR RPTOR

Compounds Affecting Amino acids regulate mTORC1

#	Compound	Targets Hit	Studies
1	Sirolimus	—	300
2	torin 1	—	10
3	Everolimus	—	297
4	Ku 0063794 [Supplementary Concept]	—	7
5	pictilisib	—	25
6	ly294002	—	11
7	Rotenone	—	300
8	Thapsigargin	—	300
9	Wortmannin	—	300
10	alpelisib	—	227
11	amn082	—	29
12	Calcimycin	—	216
13	Idarubicin	—	299
14	Idazoxan	—	300
15	Niclosamide	—	299
16	triolimus [Supplementary Concept]	—	33
17	tyrphostin 9	—	2
18	egcg	—	300
19	Ursolic Acid	—	300
20	Camptothecin	—	300
21	Dequalinium	—	136
22	Disulfiram	—	297
23	Emetine	—	298
24	Epinephrine	—	299
25	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
26	Maprotiline	—	299
27	Perphenazine	—	297
28	Enoxacin	—	299

About the Amino acids regulate mTORC1 Pathway

The Amino acids regulate mTORC1 pathway is catalogued in Reactome (ID: R-HSA-9639288) and involves 4 genes. In the BiohacksAI corpus, 28 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATP6V1B2, MLST8, MTOR, RPTOR.