What compounds affect the Aggrephagy pathway?

136 compounds in the BiohacksAI corpus have documented interactions with genes in the Aggrephagy pathway (Reactome ID: R-HSA-9646399). These compounds target 23 genes within this pathway.

What genes are in the Aggrephagy pathway?

The Aggrephagy pathway involves 23 genes. Key genes include: CFTR, HDAC6, HSP90AA1, PRKN, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3E, TUBA4A.

Aggrephagy

REACTOME PATHWAY

Reactome: R-HSA-964639923 genes136 compounds

The Aggrephagy pathway (Reactome ID: R-HSA-9646399) involves 23 genes and is affected by 136 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CFTR HDAC6 HSP90AA1 PRKN TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B UBE2N VCP

Compounds Affecting Aggrephagy

#	Compound	Targets Hit	Studies
1	Nocodazole Nocodazole is	—	215
2	Colchicine	—	300
3	Vorinostat	—	299
4	Podophyllotoxin	—	14
5	vinblastine sulfate	—	81
6	Vincristine	—	299
7	Noscapine	—	300
8	Demecolcine	—	246
9	Maytansine	—	300
10	Hexachlorophene	—	300
11	Genistein	—	300
12	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
13	cycloheximide	—	300
14	kenpaullone	—	8
15	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
16	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
17	Medroxyprogesterone Acetate	—	299
18	Disulfiram	—	297
19	scriptaid	—	53
20	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
21	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
22	Quercetin	—	300
23	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
24	piceatannol	—	300
25	Clotrimazole	—	296
26	Anisomycin	—	247
27	Hydrocortisone	—	299
28	Betamethasone	—	299
29	Bumetanide	—	299
30	Chlorthalidone	—	299
31	Ethidium	—	300
32	Hydrocortisone	—	298
33	Cervugid [Supplementary Concept]	—	300
34	Vitamin K 3	—	300
35	Mestranol	—	300
36	Nisoldipine	—	297
37	Quinestrol	—	194
38	Budesonide	—	1,000
39	Methylene Blue	—	200
40	Prednisolone	—	1,000
41	6-Aminonicotinamide	—	300
42	alsterpaullone	—	12
43	Hyoscyamine	—	296
44	Beclomethasone	—	300
45	Carbazilquinone	—	48
46	Carbidopa	—	298
47	cardamonin	—	180
48	Desoximetasone	—	86
49	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
50	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300

About the Aggrephagy Pathway

The Aggrephagy pathway is catalogued in Reactome (ID: R-HSA-9646399) and involves 23 genes. In the BiohacksAI corpus, 136 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CFTR, HDAC6, HSP90AA1, PRKN, TUBA1A.