What genes are in the Cell recruitment (pro-inflammatory response) pathway?

The Cell recruitment (pro-inflammatory response) pathway involves 13 genes. Key genes include: APP, CASP1, CTSG, ENTPD5, GSDMD, HSP90AB1, IL1B, NFKB1, NFKB2, NLRP3.

Cell recruitment (pro-inflammatory response)

Q: What compounds affect the Cell recruitment (pro-inflammatory response) pathway?

132 compounds in the BiohacksAI corpus have documented interactions with genes in the Cell recruitment (pro-inflammatory response) pathway (Reactome ID: R-HSA-9664424). These compounds target 13 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-966442413 genes132 compounds

The Cell recruitment (pro-inflammatory response) pathway (Reactome ID: R-HSA-9664424) involves 13 genes and is affected by 132 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP CASP1 CTSG ENTPD5 GSDMD HSP90AB1 IL1B NFKB1 NFKB2 NLRP3 P2RX4 P2RX7 RELA

Compounds Affecting Cell recruitment (pro-inflammatory response)

#	Compound	Targets Hit	Studies
1	Disulfiram	—	297
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Quercetin	—	300
4	Bortezomib	—	300
5	Resveratrol	—	298
6	Kaempferols	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	streptonigrin	—	299
9	Podophyllotoxin	—	14
10	Rutin	—	300
11	Withania	—	500
12	Hexachlorophene	—	300
13	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
14	tamarixetin	—	26
15	Trifluridine	—	295
16	withaferin	—	300
17	Hydrocortisone	—	299
18	Anisomycin	—	247
19	Chlorhexidine	—	299
20	cycloheximide	—	300
21	Digitoxin	—	300
22	Digoxin	—	299
23	Hydrocortisone	—	298
24	Niclosamide	—	299
25	Masoprocol	—	300
26	tyrphostin 9	—	2
27	egcg	—	300
28	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
29	caffeic acid	—	300
30	Ethinyl Estradiol	—	300
31	Thioridazine	—	35
32	Adenosine Triphosphate	—	300
33	Budesonide	—	1,000
34	Prednisolone	—	1,000
35	alsterpaullone	—	12
36	Antipyrine	—	299
37	Astemizole Antihistamine drug now withdrawn from	—	280
38	Beclomethasone	—	300
39	Betamethasone	—	299
40	Biotin	—	297
41	Bisphenol A-Glycidyl Methacrylate	—	197
42	Carbazilquinone	—	48
43	cardamonin	—	180
44	Dichlororibofuranosylbenzimidazole	—	26
45	Diethylnitrosamine	—	300
46	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
47	Dinitrochlorobenzene	—	300
48	Ethidium	—	300
49	Fluocinolone Acetonide	—	295
50	Fluorometholone	—	299

About the Cell recruitment (pro-inflammatory response) Pathway

The Cell recruitment (pro-inflammatory response) pathway is catalogued in Reactome (ID: R-HSA-9664424) and involves 13 genes. In the BiohacksAI corpus, 132 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, CASP1, CTSG, ENTPD5, GSDMD.