What compounds affect the RND3 GTPase cycle pathway?

26 compounds in the BiohacksAI corpus have documented interactions with genes in the RND3 GTPase cycle pathway (Reactome ID: R-HSA-9696264). These compounds target 6 genes within this pathway.

What genes are in the RND3 GTPase cycle pathway?

The RND3 GTPase cycle pathway involves 6 genes. Key genes include: ARHGAP35, CCDC88A, EPHA2, NISCH, PIK3R1, PIK3R2.

RND3 GTPase cycle

REACTOME PATHWAY

Reactome: R-HSA-96962646 genes26 compounds

The RND3 GTPase cycle pathway (Reactome ID: R-HSA-9696264) involves 6 genes and is affected by 26 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ARHGAP35 CCDC88A EPHA2 NISCH PIK3R1 PIK3R2

Compounds Affecting RND3 GTPase cycle

#	Compound	Targets Hit	Studies
1	pictilisib	—	25
2	ly294002	—	11
3	Sirolimus	—	300
4	Clonidine	—	299
5	Rilmenidine Oxazole derivative that acts as	—	300
6	Idazoxan	—	300
7	Naphazoline	—	298
8	Guanabenz	—	298
9	Oxymetazoline	—	298
10	Guanfacine	—	294
11	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
12	Mescaline Hallucinogenic alkaloid isolated from	—	300
13	Phentolamine	—	300
14	Wortmannin	—	300
15	alpelisib	—	227
16	torin 1	—	10
17	Quercetin	—	300
18	Idarubicin	—	299
19	Aurintricarboxylic Acid	—	184
20	Daunorubicin	—	298
21	Topotecan	—	300
22	Sorafenib	—	300
23	Dasatinib	—	299
24	Crizotinib	—	298
25	Hydrocortisone	—	299
26	Hydrocortisone	—	298

About the RND3 GTPase cycle Pathway

The RND3 GTPase cycle pathway is catalogued in Reactome (ID: R-HSA-9696264) and involves 6 genes. In the BiohacksAI corpus, 26 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARHGAP35, CCDC88A, EPHA2, NISCH, PIK3R1.