What compounds affect the Paracetamol ADME pathway?

82 compounds in the BiohacksAI corpus have documented interactions with genes in the Paracetamol ADME pathway (Reactome ID: R-HSA-9753281). These compounds target 12 genes within this pathway.

What genes are in the Paracetamol ADME pathway?

The Paracetamol ADME pathway involves 12 genes. Key genes include: ABCC1, ABCC2, ABCC3, ABCC4, ABCC5, ABCG2, CYP2E1, GSTP1, UGT1A1, UGT1A10.

Paracetamol ADME

REACTOME PATHWAY

Reactome: R-HSA-975328112 genes82 compounds

The Paracetamol ADME pathway (Reactome ID: R-HSA-9753281) involves 12 genes and is affected by 82 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC1 ABCC2 ABCC3 ABCC4 ABCC5 ABCG2 CYP2E1 GSTP1 UGT1A1 UGT1A10 UGT1A6 UGT1A9

Compounds Affecting Paracetamol ADME

#	Compound	Targets Hit	Studies
1	Delavirdine	—	296
2	Rimonabant	—	300
3	Abacavir	—	295
4	cefaclor	—	299
5	Cefamandole Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as	—	300
6	Cefmetazole	—	300
7	Cefoperazone Semisynthetic broad-spectrum cephalosporin with	—	300
8	Cefoxitin	—	300
9	Ceftriaxone	—	299
10	cefuroxime	—	299
11	Cephradine	—	298
12	Emtricitabine	—	292
13	Lamivudine	—	299
14	scutellarein	—	113
15	Olmesartan Medoxomil	—	300
16	licochalcone	—	267
17	Quercetin	—	300
18	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
19	Kaempferols	—	300
20	Daunorubicin	—	298
21	Febuxostat	—	297
22	Dehydroepiandrosterone Sulfate	—	300
23	Cyclic GMP Guanosine cyclic 3',5'-(hydrogen phosphate).	—	300
24	Bosentan	—	298
25	Fusidic Acid	—	300
26	Leukotriene D4	—	300
27	Troglitazone	—	299
28	Antimycin	—	300
29	Bumetanide	—	299
30	cefadroxil	—	299
31	Chloramphenicol	—	297
32	Gemfibrozil	—	297
33	Glyburide	—	298
34	Irbesartan	—	298
35	Leukotriene E4	—	300
36	Meloxicam	—	299
37	Nitrendipine	—	299
38	Pioglitazone	—	297
39	Sulindac	—	297
40	Trazodone	—	297
41	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
42	chrysin	—	300
43	Genistein	—	300
44	3',4'-didemethylnobiletin [Supplementary Concept]	—	300
45	Atorvastatin	—	1,000
46	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
47	Sirolimus	—	300
48	Avapritinib	—	246
49	candesartan cilexetil [Supplementary Concept]	—	300
50	Caspofungin	—	299

About the Paracetamol ADME Pathway

The Paracetamol ADME pathway is catalogued in Reactome (ID: R-HSA-9753281) and involves 12 genes. In the BiohacksAI corpus, 82 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC1, ABCC2, ABCC3, ABCC4, ABCC5.