What compounds affect the Retinoid metabolism and transport pathway?

41 compounds in the BiohacksAI corpus have documented interactions with genes in the Retinoid metabolism and transport pathway (Reactome ID: R-HSA-975634). These compounds target 7 genes within this pathway.

What genes are in the Retinoid metabolism and transport pathway?

The Retinoid metabolism and transport pathway involves 7 genes. Key genes include: AKR1B10, AKR1C1, AKR1C3, AKR1C4, PNLIP, RBP4, TTR.

Retinoid metabolism and transport

REACTOME PATHWAY

Reactome: R-HSA-9756347 genes41 compounds

The Retinoid metabolism and transport pathway (Reactome ID: R-HSA-975634) involves 7 genes and is affected by 41 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKR1B10 AKR1C1 AKR1C3 AKR1C4 PNLIP RBP4 TTR

Compounds Affecting Retinoid metabolism and transport

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	egcg	—	300
4	Kaempferols	—	300
5	Vitamin	—	295
6	Quercetin	—	300
7	Medroxyprogesterone Acetate	—	299
8	Niflumic Acid	—	300
9	Thyroxine	—	994
10	pterostilbene	—	299
11	piceatannol	—	300
12	Thyroxine	—	300
13	Masoprocol	—	300
14	Genistein	—	300
15	Resveratrol	—	298
16	Rosmarinic Acid	—	300
17	Dextrothyroxine	—	134
18	Gemfibrozil	—	297
19	Triiodothyronine	—	300
20	Oleanolic Acid	—	300
21	Ursolic Acid	—	300
22	Chlorogenic Acid	—	300
23	caffeic acid	—	300
24	Pueraria	—	300
25	Rutin	—	300
26	Hesperidin	—	300
27	phlorhizin	—	224
28	Sulindac	—	297
29	alphitonin [Supplementary Concept] from	—	300
30	Pennisetum	—	291
31	Indomethacin	—	297
32	Naproxen	—	1,000
33	Berberine	—	300
34	Linoleic Acid	—	300
35	Bimatoprost	—	297
36	chrysin	—	300
37	Progesterone	—	299
38	Testosterone	—	299
39	Equilin	—	216
40	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
41	rafoxanide	—	172

About the Retinoid metabolism and transport Pathway

The Retinoid metabolism and transport pathway is catalogued in Reactome (ID: R-HSA-975634) and involves 7 genes. In the BiohacksAI corpus, 41 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKR1B10, AKR1C1, AKR1C3, AKR1C4, PNLIP.