What compounds affect the Degradation of CDH1 pathway?

79 compounds in the BiohacksAI corpus have documented interactions with genes in the Degradation of CDH1 pathway (Reactome ID: R-HSA-9766229). These compounds target 36 genes within this pathway.

What genes are in the Degradation of CDH1 pathway?

The Degradation of CDH1 pathway involves 36 genes. Key genes include: ADRM1, CTSL, FYN, MDM2, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6.

Degradation of CDH1

REACTOME PATHWAY

Reactome: R-HSA-976622936 genes79 compounds

The Degradation of CDH1 pathway (Reactome ID: R-HSA-9766229) involves 36 genes and is affected by 79 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CTSL FYN MDM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2+6 more

Compounds Affecting Degradation of CDH1

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Niclosamide	—	299
4	egcg	—	300
5	Quercetin	—	300
6	Genistein	—	300
7	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
8	Dasatinib	—	299
9	tyrphostin ag 1478	—	4
10	Sorafenib	—	300
11	Crizotinib	—	298
12	kenpaullone	—	8
13	Digoxin	—	299
14	Calcimycin	—	216
15	cycloheximide	—	300
16	Cytarabine	—	297
17	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
18	Tubercidin	—	300
19	Anisomycin	—	247
20	Astemizole Antihistamine drug now withdrawn from	—	280
21	Azacitidine	—	298
22	Azacitidine	—	300
23	Chlorhexidine	—	299
24	Ciclopirox	—	88
25	Cladribine	—	297
26	Colchicine	—	300
27	colchine	—	2
28	Demecolcine	—	246
29	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
30	Fluspirilene	—	74
31	gedunin	—	54
32	Hexachlorophene	—	300
33	lidoflazine	—	278
34	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
35	Nisoldipine	—	297
36	Nocodazole Nocodazole is	—	215
37	Ouabain	—	300
38	paxilline	—	42
39	Podophyllotoxin	—	14
40	rafoxanide	—	172
41	streptonigrin	—	299
42	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
43	Trifluridine	—	295
44	tyrphostin 9	—	2
45	vinblastine sulfate	—	81
46	Methylene Blue	—	200
47	Sertraline	—	1,000
48	Simvastatin	—	1,000
49	Ursolic Acid	—	300
50	Methotrexate	—	289

About the Degradation of CDH1 Pathway

The Degradation of CDH1 pathway is catalogued in Reactome (ID: R-HSA-9766229) and involves 36 genes. In the BiohacksAI corpus, 79 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CTSL, FYN, MDM2, PSMA1.