What compounds affect the GABA receptor activation pathway?

51 compounds in the BiohacksAI corpus have documented interactions with genes in the GABA receptor activation pathway (Reactome ID: R-HSA-977443). These compounds target 21 genes within this pathway.

What genes are in the GABA receptor activation pathway?

The GABA receptor activation pathway involves 21 genes. Key genes include: ADCY9, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1.

GABA receptor activation

REACTOME PATHWAY

Reactome: R-HSA-97744321 genes51 compounds

The GABA receptor activation pathway (Reactome ID: R-HSA-977443) involves 21 genes and is affected by 51 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 GABBR1 GABBR2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRQ GABRR1 GABRR2 GABRR3 GNAI1 KCNJ10 KCNJ4

Compounds Affecting GABA receptor activation

#	Compound	Targets Hit	Studies
1	gamma-Aminobutyric Acid	—	300
2	Picrotoxin	—	300
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Pregnanolone	—	298
5	Bicuculline	—	300
6	Etomidate Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or	—	299
7	chrysin	—	300
8	Androsterone	—	300
9	Ciprofloxacin	—	1,000
10	Etiocholanolone	—	300
11	Ondansetron	—	299
12	Triiodothyronine	—	300
13	Eszopiclone	—	296
14	Aurintricarboxylic Acid	—	184
15	Daunorubicin	—	298
16	Ethidium	—	300
17	Rosmarinic Acid	—	300
18	Allantoin	—	300
19	Diiodotyrosine	—	300
20	Dimethylphenylpiperazinium Iodide	—	33
21	Dipyrone	—	298
22	Idarubicin	—	299
23	iodoform	—	272
24	Nicergoline	—	300
25	Pseudoephedrine	—	298
26	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
27	tiopronin	—	299
28	tyrphostin ag 1478	—	4
29	Carmustine	—	297
30	Edaravone	—	298
31	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
32	Iodoacetamide	—	300
33	Cisplatin	—	300
34	Cilostazol	—	297
35	Disulfiram	—	297
36	Physostigmine	—	300
37	Ethylmaleimide	—	300
38	Physostigmine	—	299
39	tyrphostin 1	—	1
40	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
41	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
42	Diamide	—	300
43	Dasatinib	—	299
44	N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]	—	8
45	Etazolate	—	66
46	Arachidonic Acid	—	245
47	Spermidine	—	241
48	Putrescine	—	300
49	SCH 23390 [Supplementary Concept]	—	126
50	Spermine	—	300

About the GABA receptor activation Pathway

The GABA receptor activation pathway is catalogued in Reactome (ID: R-HSA-977443) and involves 21 genes. In the BiohacksAI corpus, 51 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, GABBR1, GABBR2, GABRA1, GABRA2.