What compounds affect the Maternal to zygotic transition (MZT) pathway?

206 compounds in the BiohacksAI corpus have documented interactions with genes in the Maternal to zygotic transition (MZT) pathway (Reactome ID: R-HSA-9816359). These compounds target 15 genes within this pathway.

What genes are in the Maternal to zygotic transition (MZT) pathway?

The Maternal to zygotic transition (MZT) pathway involves 15 genes. Key genes include: AGO2, AICDA, CREBBP, EIF4A1, EIF4G1, EP300, KDM4E, KDM5B, KDM6B, PABPC1.

Maternal to zygotic transition (MZT)

REACTOME PATHWAY

Reactome: R-HSA-981635915 genes206 compounds

The Maternal to zygotic transition (MZT) pathway (Reactome ID: R-HSA-9816359) involves 15 genes and is affected by 206 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AGO2 AICDA CREBBP EIF4A1 EIF4G1 EP300 KDM4E KDM5B KDM6B PABPC1 SRPK1 TEAD4 TP53 UHRF1 YAP1

Compounds Affecting Maternal to zygotic transition (MZT)

#	Compound	Targets Hit	Studies
1	Ethidium	—	300
2	Hexachlorophene	—	300
3	Azacitidine	—	298
4	Azacitidine	—	300
5	cycloheximide	—	300
6	Nocodazole Nocodazole is	—	215
7	Colchicine	—	300
8	tyrphostin 9	—	2
9	Methylene Blue	—	200
10	Rotenone	—	300
11	Dactinomycin	—	297
12	Daunorubicin	—	298
13	Axitinib	—	298
14	plumbagin [Supplementary Concept]	—	300
15	Camptothecin	—	300
16	Genistein	—	300
17	Resveratrol	—	298
18	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
19	Demeclocycline	—	5
20	Benzalkonium Compounds	—	299
21	celastrol	—	300
22	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
23	Idarubicin	—	299
24	sp600125	—	117
25	triolimus [Supplementary Concept]	—	33
26	Pueraria	—	300
27	Antimycin	—	300
28	Emetine	—	298
29	Thapsigargin	—	300
30	Tilorone	—	300
31	Tripterygium	—	300
32	Azauridine	—	300
33	DEAD-box RNA Helicases	—	169
34	Thioctic Acid	—	298
35	Cefixime	—	300
36	Thioctic Acid	—	300
37	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
38	Methyldopa	—	297
39	egcg	—	300
40	Oxytetracycline	—	300
41	Ethinyl Estradiol	—	300
42	Bortezomib	—	300
43	Azathioprine	—	300
44	Cladribine	—	297
45	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
46	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
47	Cytarabine	—	297
48	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
49	Melphalan	—	300
50	Niclosamide	—	299

About the Maternal to zygotic transition (MZT) Pathway

The Maternal to zygotic transition (MZT) pathway is catalogued in Reactome (ID: R-HSA-9816359) and involves 15 genes. In the BiohacksAI corpus, 206 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGO2, AICDA, CREBBP, EIF4A1, EIF4G1.