What compounds target YAP1?

BiohacksAI has identified 41 compounds that interact with YAP1 (Yes1 associated transcriptional regulator). Top compounds include: Colchicine, Resveratrol, Daunorubicin, Rotenone, Pueraria. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is YAP1 (Yes1 associated transcriptional)?

YAP1 is Yes1 associated transcriptional regulator. It is a molecular target for 41 compounds documented in PubMed bioassay data. UniProt ID: P46937. NCBI Gene ID: 10413.

YAP1

MOLECULAR TARGET

Yes1 associated transcriptional regulator

UniProt: P46937 NCBI Gene: 1041341 compounds

YAP1 (Yes1 associated transcriptional regulator) is targeted by 41 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting YAP1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Colchicine	1.61	4
2	Resveratrol	1.39	3
3	Daunorubicin	1.39	3
4	Rotenone	1.39	3
5	Pueraria	1.10	2
6	Azacitidine	1.10	2
7	Azacitidine	1.10	2
8	Camptothecin	1.10	2
9	cycloheximide	1.10	2
10	Dactinomycin	1.10	2
11	deguelin [Supplementary Concept]	1.10	2
12	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	1.10	2
13	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	1.10	2
14	Ouabain	1.10	2
15	Podophyllotoxin	1.10	2
16	Thapsigargin	1.10	2
17	Berberine	0.69	1
18	Genistein	0.69	1
19	2-Methoxyestradiol	0.69	1
20	Anisomycin	0.69	1
21	Antimycin	0.69	1
22	Azauridine	0.69	1
23	Benzalkonium Compounds	0.69	1
24	celastrol	0.69	1
25	Cetylpyridinium Cationic bactericidal surfactant used as	0.69	1
26	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	0.69	1
27	dihydrorotenone	0.69	1
28	Emetine	0.69	1
29	Gliotoxin	0.69	1
30	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	0.69	1
31	Monensin	0.69	1
32	Monocrotaline	0.69	1
33	Nigericin	0.69	1
34	Nocodazole Nocodazole is	0.69	1
35	Plicamycin	0.69	1
36	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	0.69	1
37	Tilorone	0.69	1
38	Tripterygium	0.69	1
39	Tubercidin	0.69	1
40	tyrphostin 9	0.69	1
41	Valinomycin	0.69	1

About YAP1 as a Drug Target

YAP1 (Yes1 associated transcriptional regulator) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 41 compounds with documented YAP1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

YAP1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.