NFE2L2 regulating anti-oxidant/detoxification enzymes

Q: What compounds affect the NFE2L2 regulating anti-oxidant/detoxification enzymes pathway?

208 compounds in the BiohacksAI corpus have documented interactions with genes in the NFE2L2 regulating anti-oxidant/detoxification enzymes pathway (Reactome ID: R-HSA-9818027). These compounds target 6 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-98180276 genes208 compounds

The NFE2L2 regulating anti-oxidant/detoxification enzymes pathway (Reactome ID: R-HSA-9818027) involves 6 genes and is affected by 208 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREBBP EP300 GSR NFE2L2 NQO1 PRDX1

Compounds Affecting NFE2L2 regulating anti-oxidant/detoxification enzymes

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Methylene Blue	—	200
3	alyssin [Supplementary Concept]	—	300
4	Vitamin K 3	—	300
5	Nocodazole Nocodazole is	—	215
6	Carmustine	—	297
7	Meloxicam	—	299
8	Papaverine	—	299
9	Resveratrol	—	298
10	Vitamin	—	295
11	Azacitidine	—	298
12	Azacitidine	—	300
13	Genistein	—	300
14	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
15	alpha-Linolenic Acid	—	300
16	Oxymetholone	—	298
17	Rotenone	—	300
18	Ethoxyquin Antioxidant; also	—	180
19	Nitrofurazone	—	300
20	Quercetin	—	300
21	Azathioprine	—	300
22	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
23	Mestranol	—	300
24	methoprene	—	300
25	Niclosamide	—	299
26	Phenelzine	—	2
27	vinblastine sulfate	—	81
28	chrysin	—	300
29	Digitoxin	—	300
30	Digoxin	—	299
31	Flutamide	—	298
32	Hexachlorophene	—	300
33	Linoleic Acid	—	300
34	Nitrofurantoin	—	297
35	Ouabain	—	300
36	Podophyllotoxin	—	14
37	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
38	Toxaphene	—	299
39	DEAD-box RNA Helicases	—	169
40	Thioctic Acid	—	298
41	amlexanox	—	96
42	Bortezomib	—	300
43	Chlormadinone Acetate	—	300
44	Ethidium	—	300
45	Feprazone	—	63
46	Idazoxan	—	300
47	Leflunomide	—	297
48	Oxyphenbutazone	—	300
49	Thioctic Acid	—	300
50	Caffeine	—	299

About the NFE2L2 regulating anti-oxidant/detoxification enzymes Pathway

The NFE2L2 regulating anti-oxidant/detoxification enzymes pathway is catalogued in Reactome (ID: R-HSA-9818027) and involves 6 genes. In the BiohacksAI corpus, 208 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREBBP, EP300, GSR, NFE2L2, NQO1.