What compounds affect the Formation of definitive endoderm pathway?

64 compounds in the BiohacksAI corpus have documented interactions with genes in the Formation of definitive endoderm pathway (Reactome ID: R-HSA-9823730). These compounds target 3 genes within this pathway.

What genes are in the Formation of definitive endoderm pathway?

The Formation of definitive endoderm pathway involves 3 genes. Key genes include: SMAD2, SMAD3, TCF7L2.

Formation of definitive endoderm

REACTOME PATHWAY

Reactome: R-HSA-98237303 genes64 compounds

The Formation of definitive endoderm pathway (Reactome ID: R-HSA-9823730) involves 3 genes and is affected by 64 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

SMAD2 SMAD3 TCF7L2

Compounds Affecting Formation of definitive endoderm

#	Compound	Targets Hit	Studies
1	cycloheximide	—	300
2	Azacitidine	—	298
3	Azacitidine	—	300
4	Disulfiram	—	297
5	Nisoldipine	—	297
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Kaempferols	—	300
8	Quercetin	—	300
9	Colchicine	—	300
10	Dactinomycin	—	297
11	Danazol	—	298
12	Dasatinib	—	299
13	Dinitrochlorobenzene	—	300
14	Ethidium	—	300
15	Flutamide	—	298
16	Loratadine	—	296
17	Oxyphenbutazone	—	300
18	Podophyllotoxin	—	14
19	vinblastine sulfate	—	81
20	Vincristine	—	299
21	chrysin	—	300
22	egcg	—	300
23	Fluoxetine	—	1,000
24	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
25	Astemizole Antihistamine drug now withdrawn from	—	280
26	Bortezomib	—	300
27	Celecoxib	—	295
28	Ciclopirox	—	88
29	Cladribine	—	297
30	Daunorubicin	—	298
31	Domperidone	—	299
32	Emetine	—	298
33	Equilin	—	216
34	Ethinyl Estradiol	—	300
35	Ezetimibe	—	296
36	Idazoxan	—	300
37	Lynestrenol	—	299
38	Nocodazole Nocodazole is	—	215
39	Masoprocol	—	300
40	o-Phthalaldehyde	—	300
41	Perphenazine	—	297
42	pivampicillin	—	275
43	Promethazine	—	121
44	Rotenone	—	300
45	Salmeterol Xinafoate	—	227
46	Sulbactam	—	299
47	trequinsin hydrochloride	—	1
48	triflupromazine hydrochloride	—	12
49	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
50	Calcimycin	—	216

About the Formation of definitive endoderm Pathway

The Formation of definitive endoderm pathway is catalogued in Reactome (ID: R-HSA-9823730) and involves 3 genes. In the BiohacksAI corpus, 64 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include SMAD2, SMAD3, TCF7L2.