What compounds affect the MITF-M-dependent gene expression pathway?

140 compounds in the BiohacksAI corpus have documented interactions with genes in the MITF-M-dependent gene expression pathway (Reactome ID: R-HSA-9856651). These compounds target 19 genes within this pathway.

What genes are in the MITF-M-dependent gene expression pathway?

The MITF-M-dependent gene expression pathway involves 19 genes. Key genes include: AGO2, ATP6V1B2, BCL2A1, BRCA1, CCNB1, CDC25B, CDK2, CREB1, HDAC1, MAPK14.

MITF-M-dependent gene expression

REACTOME PATHWAY

Reactome: R-HSA-985665119 genes140 compounds

The MITF-M-dependent gene expression pathway (Reactome ID: R-HSA-9856651) involves 19 genes and is affected by 140 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AGO2 ATP6V1B2 BCL2A1 BRCA1 CCNB1 CDC25B CDK2 CREB1 HDAC1 MAPK14 MET MITF PLK1 SERPINE1 SIRT1 SMARCA2 TCF7L2 TERT TYR

Compounds Affecting MITF-M-dependent gene expression

#	Compound	Targets Hit	Studies
1	egcg	—	300
2	chrysin	—	300
3	Quercetin	—	300
4	Ethidium	—	300
5	Aurintricarboxylic Acid	—	184
6	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
7	cycloheximide	—	300
8	Oxyphenbutazone	—	300
9	Azacitidine	—	298
10	Azacitidine	—	300
11	Bortezomib	—	300
12	Ciclopirox	—	88
13	Nocodazole Nocodazole is	—	215
14	Disulfiram	—	297
15	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
16	Hexachlorophene	—	300
17	kenpaullone	—	8
18	alsterpaullone	—	12
19	Oxytetracycline	—	300
20	colchine	—	2
21	Anisomycin	—	247
22	Astemizole Antihistamine drug now withdrawn from	—	280
23	Calcimycin	—	216
24	Camptothecin	—	300
25	celastrol	—	300
26	Demecolcine	—	246
27	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
28	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
29	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
30	Niclosamide	—	299
31	pictilisib	—	25
32	Podophyllotoxin	—	14
33	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
34	vinblastine sulfate	—	81
35	Vorinostat	—	299
36	Genistein	—	300
37	Dasatinib	—	299
38	Daunorubicin	—	298
39	Nisoldipine	—	297
40	Resveratrol	—	298
41	calycosin	—	300
42	Oleic Acid	—	112
43	Sorafenib	—	300
44	Afatinib	—	297
45	fisetin	—	78
46	Celecoxib	—	295
47	Methylergonovine	—	14
48	sp600125	—	117
49	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
50	Cefdinir	—	298

About the MITF-M-dependent gene expression Pathway

The MITF-M-dependent gene expression pathway is catalogued in Reactome (ID: R-HSA-9856651) and involves 19 genes. In the BiohacksAI corpus, 140 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGO2, ATP6V1B2, BCL2A1, BRCA1, CCNB1.