Dengue virus activates/modulates innate and adaptive immune responses

Q: What compounds affect the Dengue virus activates/modulates innate and adaptive immune responses pathway?

42 compounds in the BiohacksAI corpus have documented interactions with genes in the Dengue virus activates/modulates innate and adaptive immune responses pathway (Reactome ID: R-HSA-9920588). These compounds target 4 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-99205884 genes42 compounds

The Dengue virus activates/modulates innate and adaptive immune responses pathway (Reactome ID: R-HSA-9920588) involves 4 genes and is affected by 42 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CGAS HSP90AA1 HSP90AB1 IKBKE

Compounds Affecting Dengue virus activates/modulates innate and adaptive immune responses

#	Compound	Targets Hit	Studies
1	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
2	Idarubicin	—	299
3	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
4	triolimus [Supplementary Concept]	—	33
5	monorden	—	8
6	gedunin	—	54
7	celastrol	—	300
8	Novobiocin	—	300
9	caffeic acid	—	300
10	Masoprocol	—	300
11	Tetracycline	—	300
12	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
13	Quercetin	—	300
14	ag490	—	14
15	Disulfiram	—	297
16	Hexachlorophene	—	300
17	piceatannol	—	300
18	Nitroprusside	—	299
19	amlexanox	—	96
20	2-Chloroadenosine 2-Chloroadenosine.	—	300
21	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
22	Calcimycin	—	216
23	Calcitriol	—	300
24	Ciclopirox	—	88
25	Clotrimazole	—	296
26	cycloheximide	—	300
27	deguelin [Supplementary Concept]	—	151
28	Indazoles	—	300
29	Miconazole	—	298
30	specioside	—	6
31	Wortmannin	—	300
32	Suramin	—	300
33	Aurintricarboxylic Acid	—	184
34	Epirubicin	—	300
35	Daunorubicin	—	298
36	Nisoldipine	—	297
37	egcg	—	300
38	Dequalinium	—	136
39	Folic Acid	—	296
40	piromidic acid	—	64
41	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
42	Crizotinib	—	298

About the Dengue virus activates/modulates innate and adaptive immune responses Pathway

The Dengue virus activates/modulates innate and adaptive immune responses pathway is catalogued in Reactome (ID: R-HSA-9920588) and involves 4 genes. In the BiohacksAI corpus, 42 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CGAS, HSP90AA1, HSP90AB1, IKBKE.