What compounds target HNMT?

BiohacksAI has identified 37 compounds that interact with HNMT (histamine N-methyltransferase). Top compounds include: Crizotinib, Calcimycin, Dequalinium, Ticagrelor, tyrphostin ag 1478. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is HNMT (histamine N-methyltransferase)?

HNMT is histamine N-methyltransferase. It is a molecular target for 37 compounds documented in PubMed bioassay data. UniProt ID: P50135. NCBI Gene ID: 3176.

HNMT

MOLECULAR TARGET

histamine N-methyltransferase

UniProt: P50135 NCBI Gene: 317637 compounds

HNMT (histamine N-methyltransferase) is targeted by 37 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting HNMT

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Crizotinib	1.61	4
2	Calcimycin	1.39	3
3	Dequalinium	1.39	3
4	Ticagrelor	1.39	3
5	tyrphostin ag 1478	1.39	3
6	Aurintricarboxylic Acid	1.10	2
7	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	1.10	2
8	Chlorhexidine	1.10	2
9	Cisplatin	1.10	2
10	darapladib [Supplementary Concept]	1.10	2
11	Dasatinib	1.10	2
12	Demeclocycline	1.10	2
13	Iodoacetamide	1.10	2
14	pictilisib	1.10	2
15	Vemurafenib	1.10	2
16	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	1.10	2
17	Thyroxine	0.69	1
18	myricetin-3-O-galactopyranoside [Supplementary Concept]	0.69	1
19	Quercetin	0.69	1
20	2-Methoxyestradiol	0.69	1
21	Afatinib	0.69	1
22	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	0.69	1
23	Disulfiram	0.69	1
24	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	0.69	1
25	Estrone	0.69	1
26	Guanabenz	0.69	1
27	Methyldopa	0.69	1
28	Methylergonovine	0.69	1
29	Methysergide	0.69	1
30	piceatannol	0.69	1
31	propionylpromazine hydrochloride	0.69	1
32	scriptaid	0.69	1
33	Suramin	0.69	1
34	Thiorphan	0.69	1
35	Thyroxine	0.69	1
36	Triiodothyronine	0.69	1
37	tyrphostin 9	0.69	1

About HNMT as a Drug Target

HNMT (histamine N-methyltransferase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 37 compounds with documented HNMT interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

HNMT inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.