What compounds target NNMT?

BiohacksAI has identified 40 compounds that interact with NNMT (nicotinamide N-methyltransferase). Top compounds include: Crizotinib, Calcimycin, Dequalinium, Ticagrelor, tyrphostin ag 1478. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is NNMT (nicotinamide N-methyltransferase)?

NNMT is nicotinamide N-methyltransferase. It is a molecular target for 40 compounds documented in PubMed bioassay data. UniProt ID: P40261. NCBI Gene ID: 4837.

NNMT

MOLECULAR TARGET

nicotinamide N-methyltransferase

UniProt: P40261 NCBI Gene: 483740 compounds

NNMT (nicotinamide N-methyltransferase) is targeted by 40 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting NNMT

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Crizotinib	1.61	4
2	Calcimycin	1.39	3
3	Dequalinium	1.39	3
4	Ticagrelor	1.39	3
5	tyrphostin ag 1478	1.39	3
6	Aurintricarboxylic Acid	1.10	2
7	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	1.10	2
8	Chlorhexidine	1.10	2
9	Cisplatin	1.10	2
10	darapladib [Supplementary Concept]	1.10	2
11	Dasatinib	1.10	2
12	Demeclocycline	1.10	2
13	Iodoacetamide	1.10	2
14	pictilisib	1.10	2
15	Vemurafenib	1.10	2
16	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	1.10	2
17	Thyroxine	0.69	1
18	myricetin-3-O-galactopyranoside [Supplementary Concept]	0.69	1
19	Quercetin	0.69	1
20	same	0.69	1
21	2-Methoxyestradiol	0.69	1
22	6-Aminonicotinamide	0.69	1
23	Afatinib	0.69	1
24	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	0.69	1
25	Disulfiram	0.69	1
26	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	0.69	1
27	Estrone	0.69	1
28	Guanabenz	0.69	1
29	Methyldopa	0.69	1
30	Methylergonovine	0.69	1
31	Methysergide	0.69	1
32	piceatannol	0.69	1
33	propionylpromazine hydrochloride	0.69	1
34	s adenosylmethionine	0.69	1
35	scriptaid	0.69	1
36	Suramin	0.69	1
37	Thiorphan	0.69	1
38	Thyroxine	0.69	1
39	Triiodothyronine	0.69	1
40	tyrphostin 9	0.69	1

About NNMT as a Drug Target

NNMT (nicotinamide N-methyltransferase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 40 compounds with documented NNMT interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

NNMT inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.