What compounds target PMP22?

BiohacksAI has identified 67 compounds that interact with PMP22 (peripheral myelin protein 22). Top compounds include: Bromodeoxyuridine, Cetomacrogol Non-ionic surfactant of, Colchicine, Nitroblue Tetrazolium Colorless to yellow dye that is reducible to blue or black formazan crystals by certain cells; formerly used to distinguish between nonbacterial and bacterial diseases,, Masoprocol. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is PMP22 (peripheral myelin protein)?

PMP22 is peripheral myelin protein 22. It is a molecular target for 67 compounds documented in PubMed bioassay data. UniProt ID: P25094. NCBI Gene ID: 24660.

PMP22

MOLECULAR TARGET

peripheral myelin protein 22

UniProt: P25094 NCBI Gene: 2466067 compounds

PMP22 (peripheral myelin protein 22) is targeted by 67 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting PMP22

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Bromodeoxyuridine	1.10	2
2	Cetomacrogol Non-ionic surfactant of	1.10	2
3	Colchicine	1.10	2
4	Nitroblue Tetrazolium Colorless to yellow dye that is reducible to blue or black formazan crystals by certain cells; formerly used to distinguish between nonbacterial and bacterial diseases,	1.10	2
5	Masoprocol	1.10	2
6	Podophyllotoxin	1.10	2
7	Sorafenib	1.10	2
8	trequinsin hydrochloride	1.10	2
9	Vincristine	1.10	2
10	Ubiquinone	0.69	1
11	Ubiquinone	0.69	1
12	Duloxetine Hydrochloride	0.69	1
13	Genistein	0.69	1
14	Testosterone	0.69	1
15	Amoxapine	0.69	1
16	Aripiprazole	0.69	1
17	Astemizole Antihistamine drug now withdrawn from	0.69	1
18	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	0.69	1
19	Ciclopirox	0.69	1
20	cinacalcet	0.69	1
21	Daunorubicin	0.69	1
22	Delavirdine	0.69	1
23	Dequalinium	0.69	1
24	Dihydroergotamine	0.69	1
25	dilazep	0.69	1
26	Disulfiram	0.69	1
27	Domperidone	0.69	1
28	Enalapril	0.69	1
29	Ethinyl Estradiol	0.69	1
30	Ethylestrenol	0.69	1
31	Ethylmorphine	0.69	1
32	Fluspirilene	0.69	1
33	Hexachlorophene	0.69	1
34	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	0.69	1
35	Idarubicin	0.69	1
36	Levobunolol	0.69	1
37	Levonorgestrel	0.69	1
38	Maprotiline	0.69	1
39	Melphalan	0.69	1
40	Vitamin K 3	0.69	1
41	Miconazole	0.69	1
42	Misoprostol	0.69	1
43	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	0.69	1
44	Niclosamide	0.69	1
45	Nisoldipine	0.69	1
46	Nitrofurazone	0.69	1
47	Nocodazole Nocodazole is	0.69	1
48	Norepinephrine Precursor of epinephrine that is secreted by	0.69	1
49	Norgestrel	0.69	1
50	Nortriptyline	0.69	1

Showing top 50 of 67 compounds. Use the BiohacksAI search to explore all PMP22 modulators.

About PMP22 as a Drug Target

PMP22 (peripheral myelin protein 22) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 67 compounds with documented PMP22 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

PMP22 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.