What compounds target PNMT?

BiohacksAI has identified 39 compounds that interact with PNMT (phenylethanolamine N-methyltransferase). Top compounds include: same, s adenosylmethionine, Crizotinib, Calcimycin, Dequalinium. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is PNMT (phenylethanolamine N-methyltransferase)?

PNMT is phenylethanolamine N-methyltransferase. It is a molecular target for 39 compounds documented in PubMed bioassay data. UniProt ID: P11086. NCBI Gene ID: 5409.

PNMT

MOLECULAR TARGET

phenylethanolamine N-methyltransferase

UniProt: P11086 NCBI Gene: 540939 compounds

PNMT (phenylethanolamine N-methyltransferase) is targeted by 39 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting PNMT

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	same	2.30	9
2	s adenosylmethionine	2.30	9
3	Crizotinib	1.61	4
4	Calcimycin	1.39	3
5	Dequalinium	1.39	3
6	Ticagrelor	1.39	3
7	tyrphostin ag 1478	1.39	3
8	Aurintricarboxylic Acid	1.10	2
9	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	1.10	2
10	Chlorhexidine	1.10	2
11	Cisplatin	1.10	2
12	darapladib [Supplementary Concept]	1.10	2
13	Dasatinib	1.10	2
14	Demeclocycline	1.10	2
15	Iodoacetamide	1.10	2
16	pictilisib	1.10	2
17	Vemurafenib	1.10	2
18	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	1.10	2
19	Thyroxine	0.69	1
20	myricetin-3-O-galactopyranoside [Supplementary Concept]	0.69	1
21	Quercetin	0.69	1
22	2-Methoxyestradiol	0.69	1
23	Afatinib	0.69	1
24	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	0.69	1
25	Disulfiram	0.69	1
26	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	0.69	1
27	Estrone	0.69	1
28	Guanabenz	0.69	1
29	Methyldopa	0.69	1
30	Methylergonovine	0.69	1
31	Methysergide	0.69	1
32	piceatannol	0.69	1
33	propionylpromazine hydrochloride	0.69	1
34	scriptaid	0.69	1
35	Suramin	0.69	1
36	Thiorphan	0.69	1
37	Thyroxine	0.69	1
38	Triiodothyronine	0.69	1
39	tyrphostin 9	0.69	1

About PNMT as a Drug Target

PNMT (phenylethanolamine N-methyltransferase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 39 compounds with documented PNMT interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

PNMT inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.