Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha

Q: What compounds affect the Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway?

59 compounds in the BiohacksAI corpus have documented interactions with genes in the Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway (Reactome ID: R-HSA-1234176). These compounds target 35 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-123417635 genes59 compounds

The Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway (Reactome ID: R-HSA-1234176) involves 35 genes and is affected by 59 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 EPAS1 HIF1A PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3+5 more

Compounds Affecting Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Emetine	—	298
4	cycloheximide	—	300
5	Topotecan	—	300
6	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
7	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
8	Harmaline	—	300
9	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
10	chrysin	—	300
11	egcg	—	300
12	Quercetin	—	300
13	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
14	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
15	Digoxin	—	299
16	gedunin	—	54
17	Tubercidin	—	300
18	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
19	Gliotoxin	—	300
20	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
21	Loratadine	—	296
22	oxatomide [Supplementary Concept] structure;	—	128
23	triolimus [Supplementary Concept]	—	33
24	Hydrocortisone	—	299
25	Kaempferols	—	300
26	Resveratrol	—	298
27	2-Chloroadenosine 2-Chloroadenosine.	—	300
28	ag490	—	14
29	Beclomethasone	—	300
30	Camptothecin	—	300
31	celastrol	—	300
32	Clotrimazole	—	296
33	cycloserine	—	298
34	Dequalinium	—	136
35	Desoximetasone	—	86
36	Epinephrine	—	299
37	Ethoxyquin Antioxidant; also	—	180
38	Fusaric Acid	—	300
39	Hesperidin	—	300
40	Hydrocortisone	—	298
41	Mometasone Furoate	—	292
42	Niclosamide	—	299
43	Nisoldipine	—	297
44	Oxytetracycline	—	300
45	Phenoxybenzamine	—	21
46	sp600125	—	117
47	tyrphostin 9	—	2
48	Wortmannin	—	300
49	Anisomycin	—	247
50	Calcimycin	—	216

About the Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Pathway

The Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway is catalogued in Reactome (ID: R-HSA-1234176) and involves 35 genes. In the BiohacksAI corpus, 59 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, EPAS1, HIF1A, PSMA1, PSMA2.