What compounds affect the Endosomal/Vacuolar pathway pathway?

37 compounds in the BiohacksAI corpus have documented interactions with genes in the Endosomal/Vacuolar pathway pathway (Reactome ID: R-HSA-1236977). These compounds target 3 genes within this pathway.

What genes are in the Endosomal/Vacuolar pathway pathway?

The Endosomal/Vacuolar pathway pathway involves 3 genes. Key genes include: CTSL, HLA-A, HLA-B.

Endosomal/Vacuolar pathway

REACTOME PATHWAY

Reactome: R-HSA-12369773 genes37 compounds

The Endosomal/Vacuolar pathway pathway (Reactome ID: R-HSA-1236977) involves 3 genes and is affected by 37 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CTSL HLA-A HLA-B

Compounds Affecting Endosomal/Vacuolar pathway

#	Compound	Targets Hit	Studies
1	Camptothecin	—	300
2	Ouabain	—	300
3	withaferin	—	300
4	celastrol	—	300
5	Disulfiram	—	297
6	Idarubicin	—	299
7	Azacitidine	—	298
8	Azacitidine	—	300
9	Bortezomib	—	300
10	Calcimycin	—	216
11	Crizotinib	—	298
12	cycloheximide	—	300
13	Dactinomycin	—	297
14	Daunorubicin	—	298
15	Emetine	—	298
16	Epirubicin	—	300
17	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
18	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
19	kenpaullone	—	8
20	Proscillaridin	—	219
21	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
22	Tripterygium	—	300
23	cbd	—	298
24	Genistein	—	300
25	Sertraline	—	1,000
26	cannabidiol	—	296
27	Deslanoside Deacetyllanatoside C.	—	89
28	Digitoxin	—	300
29	Digoxin	—	299
30	Feprazone	—	63
31	Leflunomide	—	297
32	Nitrendipine	—	299
33	Phenylbutazone	—	300
34	triolimus [Supplementary Concept]	—	33
35	Thapsigargin	—	300
36	Astemizole Antihistamine drug now withdrawn from	—	280
37	Triamcinolone	—	300

About the Endosomal/Vacuolar pathway Pathway

The Endosomal/Vacuolar pathway pathway is catalogued in Reactome (ID: R-HSA-1236977) and involves 3 genes. In the BiohacksAI corpus, 37 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CTSL, HLA-A, HLA-B.