What compounds affect the Signaling by NOTCH pathway?

315 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by NOTCH pathway (Reactome ID: R-HSA-157118). These compounds target 81 genes within this pathway.

What genes are in the Signaling by NOTCH pathway?

The Signaling by NOTCH pathway involves 81 genes. Key genes include: ADAM10, ADAM17, ADRM1, AGO2, APH1A, APH1B, ARRB1, ATP2A1, ATP2A2, ATP2A3.

Signaling by NOTCH

REACTOME PATHWAY

Reactome: R-HSA-15711881 genes315 compounds

The Signaling by NOTCH pathway (Reactome ID: R-HSA-157118) involves 81 genes and is affected by 315 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM10 ADAM17 ADRM1 AGO2 APH1A APH1B ARRB1 ATP2A1 ATP2A2 ATP2A3 CCNC CDK8 CREB1 CREBBP CUL1 DLK1 EGFR ELANE EP300 FLT4 FURIN HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7+51 more

Compounds Affecting Signaling by NOTCH

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Daunorubicin	—	298
3	Reserpine	—	297
4	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
5	Vorinostat	—	299
6	Camptothecin	—	300
7	Celecoxib	—	295
8	scriptaid	—	53
9	Ursolic Acid	—	300
10	pictilisib	—	25
11	Valproic Acid	—	296
12	Butyric Acid	—	300
13	Quercetin	—	300
14	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
15	chrysin	—	300
16	egcg	—	300
17	Disulfiram	—	297
18	Nocodazole Nocodazole is	—	215
19	Kaempferols	—	300
20	Chlorogenic Acid	—	300
21	gamma-Aminobutyric Acid	—	300
22	Dihydroergocristine	—	187
23	Hexachlorophene	—	300
24	Methylene Blue	—	200
25	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
26	Axitinib	—	298
27	Genistein	—	300
28	Nisoldipine	—	297
29	Oxyphenbutazone	—	300
30	Ethidium	—	300
31	ninhydrin	—	300
32	cycloheximide	—	300
33	Harmaline	—	300
34	sp600125	—	117
35	triflupromazine hydrochloride	—	12
36	Colchicine	—	300
37	Dasatinib	—	299
38	Emetine	—	298
39	Salmeterol Xinafoate	—	227
40	Ethinyl Estradiol	—	300
41	Azacitidine	—	298
42	Azacitidine	—	300
43	Rotenone	—	300
44	Cladribine	—	297
45	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
46	Niclosamide	—	299
47	Dactinomycin	—	297
48	o-Phthalaldehyde	—	300
49	plumbagin [Supplementary Concept]	—	300
50	Resveratrol	—	298

About the Signaling by NOTCH Pathway

The Signaling by NOTCH pathway is catalogued in Reactome (ID: R-HSA-157118) and involves 81 genes. In the BiohacksAI corpus, 315 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM10, ADAM17, ADRM1, AGO2, APH1A.