What genes are in the ZBP1(DAI) mediated induction of type I IFNs pathway?

The ZBP1(DAI) mediated induction of type I IFNs pathway involves 9 genes. Key genes include: CHUK, IKBKB, NFKB1, NFKB2, NFKBIA, RELA, RIPK3, TBK1, TLR3.

ZBP1(DAI) mediated induction of type I IFNs

Q: What compounds affect the ZBP1(DAI) mediated induction of type I IFNs pathway?

52 compounds in the BiohacksAI corpus have documented interactions with genes in the ZBP1(DAI) mediated induction of type I IFNs pathway (Reactome ID: R-HSA-1606322). These compounds target 9 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-16063229 genes52 compounds

The ZBP1(DAI) mediated induction of type I IFNs pathway (Reactome ID: R-HSA-1606322) involves 9 genes and is affected by 52 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CHUK IKBKB NFKB1 NFKB2 NFKBIA RELA RIPK3 TBK1 TLR3

Compounds Affecting ZBP1(DAI) mediated induction of type I IFNs

#	Compound	Targets Hit	Studies
1	chicoric acid	—	117
2	Quercetin	—	300
3	Resveratrol	—	298
4	Bortezomib	—	300
5	Podophyllotoxin	—	14
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Kaempferols	—	300
8	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
9	Rutin	—	300
10	Withania	—	500
11	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
12	tamarixetin	—	26
13	withaferin	—	300
14	Trifluridine	—	295
15	vinblastine sulfate	—	81
16	Crizotinib	—	298
17	Hydrocortisone	—	299
18	egcg	—	300
19	Cerulenin	—	300
20	Chlorpropamide	—	300
21	daph	—	2
22	Disulfiram	—	297
23	Hexachlorophene	—	300
24	Hydrocortisone	—	298
25	Lovastatin	—	300
26	ly294002	—	11
27	Promethazine	—	121
28	protriptyline	—	296
29	streptonigrin	—	299
30	Sulfaphenazole	—	300
31	Triamcinolone	—	300
32	tyrphostin 1	—	1
33	tyrphostin ag 1478	—	4
34	Voriconazole	—	299
35	Cathelicidins Antimicrobial cationic peptides with	—	300
36	plumbagin [Supplementary Concept]	—	300
37	Ursolic Acid	—	300
38	Oleanolic Acid	—	300
39	pyrrolidine dithiocarbamate	—	275
40	Budesonide	—	1,000
41	Dibucaine	—	299
42	Dimethylphenylpiperazinium Iodide	—	33
43	Edaravone	—	298
44	Fluocinolone Acetonide	—	295
45	Sulfadimethoxine	—	300
46	alsterpaullone	—	12
47	Aurintricarboxylic Acid	—	184
48	sp600125	—	117
49	amlexanox	—	96
50	Axitinib	—	298

About the ZBP1(DAI) mediated induction of type I IFNs Pathway

The ZBP1(DAI) mediated induction of type I IFNs pathway is catalogued in Reactome (ID: R-HSA-1606322) and involves 9 genes. In the BiohacksAI corpus, 52 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CHUK, IKBKB, NFKB1, NFKB2, NFKBIA.