What compounds affect the Disease pathway?

838 compounds in the BiohacksAI corpus have documented interactions with genes in the Disease pathway (Reactome ID: R-HSA-1643685). These compounds target 427 genes within this pathway.

What genes are in the Disease pathway?

The Disease pathway involves 427 genes. Key genes include: ABCB11, ABCB6, ABCC2, ABCC8, ABCC9, ABL1, ADA, ADAM10, ADAM17, ADAMTS4.

Disease

REACTOME PATHWAY

Reactome: R-HSA-1643685427 genes838 compounds

The Disease pathway (Reactome ID: R-HSA-1643685) involves 427 genes and is affected by 838 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCB11 ABCB6 ABCC2 ABCC8 ABCC9 ABL1 ADA ADAM10 ADAM17 ADAMTS4 ADAMTS5 ADCY9 ADORA2B ADRM1 AGO2 AHCY AKT3 ALK APH1A APH1B APOBEC3G APP ARAF ARRB1 ASH2L ATIC ATM ATP1A1 ATP1A2 ATP1A3+397 more

Compounds Affecting Disease

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Sorafenib	—	300
3	Quercetin	—	300
4	Crizotinib	—	298
5	sp600125	—	117
6	Dasatinib	—	299
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
9	Hexachlorophene	—	300
10	Axitinib	—	298
11	Vorinostat	—	299
12	vinblastine sulfate	—	81
13	Podophyllotoxin	—	14
14	Nocodazole Nocodazole is	—	215
15	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
16	egcg	—	300
17	Colchicine	—	300
18	Daunorubicin	—	298
19	kenpaullone	—	8
20	Disulfiram	—	297
21	alsterpaullone	—	12
22	Kaempferols	—	300
23	pictilisib	—	25
24	Digoxin	—	299
25	cycloheximide	—	300
26	chrysin	—	300
27	Vincristine	—	299
28	Digitoxin	—	300
29	Camptothecin	—	300
30	Methylene Blue	—	200
31	Reserpine	—	297
32	Astemizole Antihistamine drug now withdrawn from	—	280
33	Demecolcine	—	246
34	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
35	Genistein	—	300
36	Ouabain	—	300
37	Niclosamide	—	299
38	Celecoxib	—	295
39	ly294002	—	11
40	Resveratrol	—	298
41	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
42	Chlorhexidine	—	299
43	Nisoldipine	—	297
44	Aurintricarboxylic Acid	—	184
45	tyrphostin ag 1478	—	4
46	Ethidium	—	300
47	Azacitidine	—	298
48	Azacitidine	—	300
49	Afatinib	—	297
50	Noscapine	—	300

About the Disease Pathway

The Disease pathway is catalogued in Reactome (ID: R-HSA-1643685) and involves 427 genes. In the BiohacksAI corpus, 838 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCB11, ABCB6, ABCC2, ABCC8, ABCC9.