What compounds affect the Vitamin D (calciferol) metabolism pathway?

79 compounds in the BiohacksAI corpus have documented interactions with genes in the Vitamin D (calciferol) metabolism pathway (Reactome ID: R-HSA-196791). These compounds target 3 genes within this pathway.

What genes are in the Vitamin D (calciferol) metabolism pathway?

The Vitamin D (calciferol) metabolism pathway involves 3 genes. Key genes include: CYP24A1, GC, VDR.

Vitamin D (calciferol) metabolism

REACTOME PATHWAY

Reactome: R-HSA-1967913 genes79 compounds

The Vitamin D (calciferol) metabolism pathway (Reactome ID: R-HSA-196791) involves 3 genes and is affected by 79 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CYP24A1 GC VDR

Compounds Affecting Vitamin D (calciferol) metabolism

#	Compound	Targets Hit	Studies
1	Calcitriol	—	300
2	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
3	Lithocholic Acid	—	300
4	Disulfiram	—	297
5	Ethidium	—	300
6	Oxyphenbutazone	—	300
7	Dactinomycin	—	297
8	Nisoldipine	—	297
9	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
10	Arachidonic Acid	—	245
11	Dehydroepiandrosterone Sulfate	—	300
12	plumbagin [Supplementary Concept]	—	300
13	alpha-Linolenic Acid	—	300
14	Dinitrochlorobenzene	—	300
15	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
16	Idazoxan	—	300
17	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
18	Vitamin K 3	—	300
19	Podophyllotoxin	—	14
20	Sodium Dodecyl Sulfate	—	300
21	Wortmannin	—	300
22	Catechin	—	51
23	chrysin	—	300
24	Night Vision Function of	—	56
25	Methotrexate	—	289
26	Amoxapine	—	259
27	Aurintricarboxylic Acid	—	184
28	Bromocriptine	—	299
29	C75-coenzyme	—	49
30	Calcifediol	—	300
31	Calcimycin	—	216
32	candesartan cilexetil [Supplementary Concept]	—	300
33	Carbaryl	—	300
34	salvin [Supplementary Concept]	—	300
35	cefaclor	—	299
36	Cefpirome	—	300
37	Colchicine	—	300
38	cycloheximide	—	300
39	d609	—	49
40	Daunorubicin	—	298
41	diallyl trisulfide	—	246
42	Diamide	—	300
43	Edaravone	—	298
44	Emetine	—	298
45	Epinephrine	—	299
46	Estramustine	—	300
47	Ethoxyquin Antioxidant; also	—	180
48	Feprazone	—	63
49	gamma-Linolenic Acid	—	300
50	Gliotoxin	—	300

About the Vitamin D (calciferol) metabolism Pathway

The Vitamin D (calciferol) metabolism pathway is catalogued in Reactome (ID: R-HSA-196791) and involves 3 genes. In the BiohacksAI corpus, 79 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CYP24A1, GC, VDR.