What compounds affect the Nicotinate metabolism pathway?

49 compounds in the BiohacksAI corpus have documented interactions with genes in the Nicotinate metabolism pathway (Reactome ID: R-HSA-196807). These compounds target 4 genes within this pathway.

What genes are in the Nicotinate metabolism pathway?

The Nicotinate metabolism pathway involves 4 genes. Key genes include: CD38, NADK, NAPRT, NNMT.

Nicotinate metabolism

REACTOME PATHWAY

Reactome: R-HSA-1968074 genes49 compounds

The Nicotinate metabolism pathway (Reactome ID: R-HSA-196807) involves 4 genes and is affected by 49 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CD38 NADK NAPRT NNMT

Compounds Affecting Nicotinate metabolism

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	Calcimycin	—	216
3	Dequalinium	—	136
4	Ticagrelor	—	299
5	tyrphostin ag 1478	—	4
6	Aurintricarboxylic Acid	—	184
7	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
8	Chlorhexidine	—	299
9	Cisplatin	—	300
10	darapladib [Supplementary Concept]	—	44
11	Dasatinib	—	299
12	Demeclocycline	—	297
13	Iodoacetamide	—	300
14	pictilisib	—	25
15	Vemurafenib	—	298
16	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
17	Thyroxine	—	994
18	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
19	Quercetin	—	300
20	same	—	299
21	2-Methoxyestradiol	—	300
22	6-Aminonicotinamide	—	300
23	Afatinib	—	297
24	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
25	Disulfiram	—	297
26	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
27	Estrone	—	300
28	Guanabenz	—	298
29	Methyldopa	—	297
30	Methylergonovine	—	193
31	Methysergide	—	300
32	piceatannol	—	300
33	propionylpromazine hydrochloride	—	2
34	s adenosylmethionine	—	300
35	scriptaid	—	53
36	Suramin	—	300
37	Thiorphan	—	300
38	Thyroxine	—	300
39	Triiodothyronine	—	300
40	tyrphostin 9	—	2
41	Salicylic Acid	—	298
42	Aminopyrine	—	300
43	Antipyrine	—	299
44	Oxyphenbutazone	—	300
45	Phenylbutazone	—	300
46	Picloram	—	211
47	Sulfinpyrazone	—	300
48	egcg	—	300
49	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150

About the Nicotinate metabolism Pathway

The Nicotinate metabolism pathway is catalogued in Reactome (ID: R-HSA-196807) and involves 4 genes. In the BiohacksAI corpus, 49 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CD38, NADK, NAPRT, NNMT.