Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Q: What compounds affect the Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway?

51 compounds in the BiohacksAI corpus have documented interactions with genes in the Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway (Reactome ID: R-HSA-198933). These compounds target 5 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-1989335 genes51 compounds

The Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway (Reactome ID: R-HSA-198933) involves 5 genes and is affected by 51 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

HLA-A HLA-B ICAM1 ITGA4 ITGB2

Compounds Affecting Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

#	Compound	Targets Hit	Studies
1	Phenylbutazone	—	300
2	Astemizole Antihistamine drug now withdrawn from	—	280
3	Lovastatin	—	300
4	Camptothecin	—	300
5	Ouabain	—	300
6	withaferin	—	300
7	celastrol	—	300
8	Disulfiram	—	297
9	Idarubicin	—	299
10	Azacitidine	—	298
11	Azacitidine	—	300
12	Bortezomib	—	300
13	Calcimycin	—	216
14	Crizotinib	—	298
15	cycloheximide	—	300
16	Dactinomycin	—	297
17	Daunorubicin	—	298
18	Emetine	—	298
19	Epirubicin	—	300
20	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
21	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
22	kenpaullone	—	8
23	Proscillaridin	—	219
24	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
25	Tripterygium	—	300
26	cbd	—	298
27	Genistein	—	300
28	Sertraline	—	1,000
29	cannabidiol	—	296
30	Deslanoside Deacetyllanatoside C.	—	89
31	Digitoxin	—	300
32	Digoxin	—	299
33	Feprazone	—	63
34	Leflunomide	—	297
35	Nitrendipine	—	299
36	triolimus [Supplementary Concept]	—	33
37	Thapsigargin	—	300
38	Inositol	—	300
39	Sulfinpyrazone	—	300
40	Chlorogenic Acid	—	300
41	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
42	Prednisolone	—	1,000
43	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
44	Enoximone	—	300
45	Isocarboxazid	—	227
46	Oxaprozin	—	181
47	Quinestrol	—	194
48	Ranolazine	—	297
49	Semustine 4-Methyl derivative of LOMUSTINE; (CCNU).	—	97
50	sulfameter	—	52

About the Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Pathway

The Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway is catalogued in Reactome (ID: R-HSA-198933) and involves 5 genes. In the BiohacksAI corpus, 51 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include HLA-A, HLA-B, ICAM1, ITGA4, ITGB2.