What compounds affect the Metabolism of amine-derived hormones pathway?

42 compounds in the BiohacksAI corpus have documented interactions with genes in the Metabolism of amine-derived hormones pathway (Reactome ID: R-HSA-209776). These compounds target 4 genes within this pathway.

What genes are in the Metabolism of amine-derived hormones pathway?

The Metabolism of amine-derived hormones pathway involves 4 genes. Key genes include: DDC, IYD, PNMT, TH.

Metabolism of amine-derived hormones

REACTOME PATHWAY

Reactome: R-HSA-2097764 genes42 compounds

The Metabolism of amine-derived hormones pathway (Reactome ID: R-HSA-209776) involves 4 genes and is affected by 42 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

DDC IYD PNMT TH

Compounds Affecting Metabolism of amine-derived hormones

#	Compound	Targets Hit	Studies
1	Methyldopa	—	297
2	Monoiodotyrosine	—	274
3	same	—	299
4	s adenosylmethionine	—	300
5	Crizotinib	—	298
6	Calcimycin	—	216
7	Dequalinium	—	136
8	Ticagrelor	—	299
9	tyrphostin ag 1478	—	4
10	Aurintricarboxylic Acid	—	184
11	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
12	Chlorhexidine	—	299
13	Cisplatin	—	300
14	darapladib [Supplementary Concept]	—	44
15	Dasatinib	—	299
16	Demeclocycline	—	297
17	Iodoacetamide	—	300
18	pictilisib	—	25
19	Vemurafenib	—	298
20	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
21	Thyroxine	—	994
22	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
23	Quercetin	—	300
24	2-Methoxyestradiol	—	300
25	Afatinib	—	297
26	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
27	Disulfiram	—	297
28	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
29	Estrone	—	300
30	Guanabenz	—	298
31	Methylergonovine	—	193
32	Methysergide	—	300
33	piceatannol	—	300
34	propionylpromazine hydrochloride	—	2
35	scriptaid	—	53
36	Suramin	—	300
37	Thiorphan	—	300
38	Thyroxine	—	300
39	Triiodothyronine	—	300
40	tyrphostin 9	—	2
41	alpha-Methyltyrosine	—	300
42	Carbidopa	—	298

About the Metabolism of amine-derived hormones Pathway

The Metabolism of amine-derived hormones pathway is catalogued in Reactome (ID: R-HSA-209776) and involves 4 genes. In the BiohacksAI corpus, 42 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include DDC, IYD, PNMT, TH.