What compounds affect the Catecholamine biosynthesis pathway?

42 compounds in the BiohacksAI corpus have documented interactions with genes in the Catecholamine biosynthesis pathway (Reactome ID: R-HSA-209905). These compounds target 3 genes within this pathway.

What genes are in the Catecholamine biosynthesis pathway?

The Catecholamine biosynthesis pathway involves 3 genes. Key genes include: DDC, PNMT, TH.

Catecholamine biosynthesis

REACTOME PATHWAY

Reactome: R-HSA-2099053 genes42 compounds

The Catecholamine biosynthesis pathway (Reactome ID: R-HSA-209905) involves 3 genes and is affected by 42 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

DDC PNMT TH

Compounds Affecting Catecholamine biosynthesis

#	Compound	Targets Hit	Studies
1	Methyldopa	—	297
2	same	—	299
3	s adenosylmethionine	—	300
4	Crizotinib	—	298
5	Calcimycin	—	216
6	Dequalinium	—	136
7	Ticagrelor	—	299
8	tyrphostin ag 1478	—	4
9	Aurintricarboxylic Acid	—	184
10	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
11	Chlorhexidine	—	299
12	Cisplatin	—	300
13	darapladib [Supplementary Concept]	—	44
14	Dasatinib	—	299
15	Demeclocycline	—	297
16	Iodoacetamide	—	300
17	pictilisib	—	25
18	Vemurafenib	—	298
19	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
20	Thyroxine	—	994
21	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
22	Quercetin	—	300
23	2-Methoxyestradiol	—	300
24	Afatinib	—	297
25	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
26	Disulfiram	—	297
27	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
28	Estrone	—	300
29	Guanabenz	—	298
30	Methylergonovine	—	193
31	Methysergide	—	300
32	piceatannol	—	300
33	propionylpromazine hydrochloride	—	2
34	scriptaid	—	53
35	Suramin	—	300
36	Thiorphan	—	300
37	Thyroxine	—	300
38	Triiodothyronine	—	300
39	tyrphostin 9	—	2
40	Monoiodotyrosine	—	274
41	alpha-Methyltyrosine	—	300
42	Carbidopa	—	298

About the Catecholamine biosynthesis Pathway

The Catecholamine biosynthesis pathway is catalogued in Reactome (ID: R-HSA-209905) and involves 3 genes. In the BiohacksAI corpus, 42 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include DDC, PNMT, TH.