Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

Q: What compounds affect the Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway?

109 compounds in the BiohacksAI corpus have documented interactions with genes in the Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway (Reactome ID: R-HSA-2173793). These compounds target 18 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-217379318 genes109 compounds

The Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway (Reactome ID: R-HSA-2173793) involves 18 genes and is affected by 109 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCNC CCNT2 CDK8 CDK9 EP300 FURIN HDAC1 MAPK1 MAPK3 MEN1 MYC NCOR1 NCOR2 PARP1 SERPINE1 SMAD2 SMAD3 STAT1

Compounds Affecting Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

#	Compound	Targets Hit	Studies
1	alsterpaullone	—	12
2	egcg	—	300
3	kenpaullone	—	8
4	Bortezomib	—	300
5	Daunorubicin	—	298
6	Sorafenib	—	300
7	Danazol	—	298
8	Loratadine	—	296
9	Podophyllotoxin	—	14
10	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
11	Celecoxib	—	295
12	Hexachlorophene	—	300
13	Nocodazole Nocodazole is	—	215
14	trequinsin hydrochloride	—	1
15	plumbagin [Supplementary Concept]	—	300
16	Vorinostat	—	299
17	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
18	Calcimycin	—	216
19	cycloheximide	—	300
20	Azacitidine	—	298
21	Azacitidine	—	300
22	Disulfiram	—	297
23	Nisoldipine	—	297
24	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
25	Kaempferols	—	300
26	Quercetin	—	300
27	Colchicine	—	300
28	Dactinomycin	—	297
29	Dasatinib	—	299
30	Dinitrochlorobenzene	—	300
31	Ethidium	—	300
32	Flutamide	—	298
33	Oxyphenbutazone	—	300
34	vinblastine sulfate	—	81
35	Vincristine	—	299
36	chrysin	—	300
37	Fluoxetine	—	1,000
38	Methylene Blue	—	200
39	Astemizole Antihistamine drug now withdrawn from	—	280
40	Ciclopirox	—	88
41	Cladribine	—	297
42	Domperidone	—	299
43	Emetine	—	298
44	Equilin	—	216
45	Ethinyl Estradiol	—	300
46	Ezetimibe	—	296
47	Idazoxan	—	300
48	Lynestrenol	—	299
49	Masoprocol	—	300
50	o-Phthalaldehyde	—	300

About the Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Pathway

The Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway is catalogued in Reactome (ID: R-HSA-2173793) and involves 18 genes. In the BiohacksAI corpus, 109 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNC, CCNT2, CDK8, CDK9, EP300.