What genes are in the Resolution of Sister Chromatid Cohesion pathway?

The Resolution of Sister Chromatid Cohesion pathway involves 29 genes. Key genes include: AURKB, BIRC5, CCNB1, CCNB2, CDK1, HDAC8, PLK1, PPP1CC, PPP2CA, PPP2R5A.

Resolution of Sister Chromatid Cohesion

Q: What compounds affect the Resolution of Sister Chromatid Cohesion pathway?

62 compounds in the BiohacksAI corpus have documented interactions with genes in the Resolution of Sister Chromatid Cohesion pathway (Reactome ID: R-HSA-2500257). These compounds target 29 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-250025729 genes62 compounds

The Resolution of Sister Chromatid Cohesion pathway (Reactome ID: R-HSA-2500257) involves 29 genes and is affected by 62 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AURKB BIRC5 CCNB1 CCNB2 CDK1 HDAC8 PLK1 PPP1CC PPP2CA PPP2R5A TAOK1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B XPO1

Compounds Affecting Resolution of Sister Chromatid Cohesion

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Nocodazole Nocodazole is	—	215
3	Vorinostat	—	299
4	Vincristine	—	299
5	Noscapine	—	300
6	Podophyllotoxin	—	14
7	Demecolcine	—	246
8	Maytansine	—	300
9	vinblastine sulfate	—	81
10	fisetin	—	78
11	kenpaullone	—	8
12	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
13	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
14	Sorafenib	—	300
15	sp600125	—	117
16	Quercetin	—	300
17	alsterpaullone	—	12
18	indirubin	—	300
19	chrysin	—	300
20	Okadaic Acid	—	300
21	Crizotinib	—	298
22	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
23	Dasatinib	—	299
24	Axitinib	—	298
25	1-(5,8-dihydro-1,4-dihydroxy-5,8-dioxo-2-naphthyl)-4-methylpent-3-en-1-yl cinnamate [Supplementary Concept]	—	54
26	Kaempferols	—	300
27	hydroxyfasudil [Supplementary Concept]	—	11
28	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
29	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
30	scutellarein	—	113
31	tamarixetin	—	26
32	Clofibrate	—	299
33	Fenofibrate	—	297
34	Sertraline	—	1,000
35	Cinnarizine	—	299
36	Clotrimazole	—	296
37	Rotenone	—	300
38	ly294002	—	11
39	Wortmannin	—	300
40	Oleic Acid	—	112
41	Simvastatin	—	1,000
42	cefaclor	—	299
43	Disulfiram	—	297
44	Hexachlorophene	—	300
45	Lithocholic Acid	—	300
46	Nisoldipine	—	297
47	Oxyphenbutazone	—	300
48	Oxytetracycline	—	300
49	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
50	scriptaid	—	53

About the Resolution of Sister Chromatid Cohesion Pathway

The Resolution of Sister Chromatid Cohesion pathway is catalogued in Reactome (ID: R-HSA-2500257) and involves 29 genes. In the BiohacksAI corpus, 62 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AURKB, BIRC5, CCNB1, CCNB2, CDK1.