What genes are in the SUMOylation of ubiquitinylation proteins pathway?

The SUMOylation of ubiquitinylation proteins pathway involves 2 genes. Key genes include: MDM2, SUMO1.

SUMOylation of ubiquitinylation proteins

Q: What compounds affect the SUMOylation of ubiquitinylation proteins pathway?

55 compounds in the BiohacksAI corpus have documented interactions with genes in the SUMOylation of ubiquitinylation proteins pathway (Reactome ID: R-HSA-3232142). These compounds target 2 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-32321422 genes55 compounds

The SUMOylation of ubiquitinylation proteins pathway (Reactome ID: R-HSA-3232142) involves 2 genes and is affected by 55 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

MDM2 SUMO1

Compounds Affecting SUMOylation of ubiquitinylation proteins

#	Compound	Targets Hit	Studies
1	Hexachlorophene	—	300
2	Digoxin	—	299
3	Calcimycin	—	216
4	cycloheximide	—	300
5	Cytarabine	—	297
6	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
7	Niclosamide	—	299
8	Tubercidin	—	300
9	Anisomycin	—	247
10	Astemizole Antihistamine drug now withdrawn from	—	280
11	Azacitidine	—	298
12	Azacitidine	—	300
13	Chlorhexidine	—	299
14	Ciclopirox	—	88
15	Cladribine	—	297
16	Colchicine	—	300
17	colchine	—	2
18	Demecolcine	—	246
19	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
20	Fluspirilene	—	74
21	gedunin	—	54
22	lidoflazine	—	278
23	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
24	Nisoldipine	—	297
25	Nocodazole Nocodazole is	—	215
26	Ouabain	—	300
27	paxilline	—	42
28	Podophyllotoxin	—	14
29	rafoxanide	—	172
30	streptonigrin	—	299
31	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
32	Trifluridine	—	295
33	tyrphostin 9	—	2
34	vinblastine sulfate	—	81
35	Methylene Blue	—	200
36	Sertraline	—	1,000
37	Simvastatin	—	1,000
38	Ursolic Acid	—	300
39	Methotrexate	—	289
40	Aripiprazole	—	298
41	cardamonin	—	180
42	dihydrorotenone	—	13
43	Dinitrochlorobenzene	—	300
44	Lovastatin	—	300
45	Melphalan	—	300
46	Nitrofurantoin	—	297
47	Oxyphenbutazone	—	300
48	propionylpromazine hydrochloride	—	2
49	sp600125	—	117
50	Spironolactone	—	298

About the SUMOylation of ubiquitinylation proteins Pathway

The SUMOylation of ubiquitinylation proteins pathway is catalogued in Reactome (ID: R-HSA-3232142) and involves 2 genes. In the BiohacksAI corpus, 55 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include MDM2, SUMO1.