What compounds affect the TRP channels pathway?

52 compounds in the BiohacksAI corpus have documented interactions with genes in the TRP channels pathway (Reactome ID: R-HSA-3295583). These compounds target 12 genes within this pathway.

What genes are in the TRP channels pathway?

The TRP channels pathway involves 12 genes. Key genes include: RIPK3, TRPC5, TRPC6, TRPM2, TRPM3, TRPM4, TRPM5, TRPM7, TRPM8, TRPV1.

TRP channels

REACTOME PATHWAY

Reactome: R-HSA-329558312 genes52 compounds

The TRP channels pathway (Reactome ID: R-HSA-3295583) involves 12 genes and is affected by 52 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

RIPK3 TRPC5 TRPC6 TRPM2 TRPM3 TRPM4 TRPM5 TRPM7 TRPM8 TRPV1 TRPV2 TRPV5

Compounds Affecting TRP channels

#	Compound	Targets Hit	Studies
1	Lysophosphatidylcholines Derivatives of PHOSPHATIDYLCHOLINES obtained by their partial hydrolysis which removes	—	300
2	Clotrimazole	—	296
3	Econazole	—	299
4	Spermine	—	300
5	cbd	—	298
6	cannabidiol	—	296
7	Arachidonic Acid	—	245
8	Adenosine Monophosphate Adenine nucleotide containing	—	300
9	Miconazole	—	298
10	Adenosine Triphosphate	—	300
11	Sphingosine	—	300
12	Hyoscyamine	—	296
13	Carvedilol	—	296
14	Propantheline	—	73
15	Methylene Blue	—	200
16	Hexachlorophene	—	300
17	Promazine	—	40
18	Promethazine	—	121
19	propionylpromazine hydrochloride	—	2
20	Thioridazine	—	35
21	triflupromazine hydrochloride	—	12
22	Duloxetine Hydrochloride	—	993
23	Amoxapine	—	259
24	Fluspirilene	—	74
25	NAD	—	300
26	NAD	—	300
27	NAD	—	300
28	Cyclic ADP-Ribose	—	300
29	Adenosine Diphosphate Ribose	—	300
30	O-Acetyl-ADP-Ribose	—	92
31	Colchicine	—	300
32	Cyclic AMP	—	300
33	Cyclic AMP	—	300
34	Emetine	—	298
35	Lasalocid Cationic ionophore antibiotic obtained from Streptomyces lasaliensis that, among other effects, dissociates	—	300
36	Pueraria	—	300
37	Genistein	—	300
38	Kaempferols	—	300
39	Progesterone	—	299
40	Quercetin	—	300
41	m084	—	2
42	Adenosine	—	298
43	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
44	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
45	Camphor	—	300
46	Framycetin	—	200
47	Leukotriene B4	—	300
48	neomycin	—	298
49	Menthol	—	300
50	Pioglitazone	—	297

About the TRP channels Pathway

The TRP channels pathway is catalogued in Reactome (ID: R-HSA-3295583) and involves 12 genes. In the BiohacksAI corpus, 52 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include RIPK3, TRPC5, TRPC6, TRPM2, TRPM3.