What compounds affect the Attenuation phase pathway?

42 compounds in the BiohacksAI corpus have documented interactions with genes in the Attenuation phase pathway (Reactome ID: R-HSA-3371568). These compounds target 9 genes within this pathway.

What genes are in the Attenuation phase pathway?

The Attenuation phase pathway involves 9 genes. Key genes include: CREBBP, EP300, FKBP4, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA8, PTGES3.

Attenuation phase

REACTOME PATHWAY

Reactome: R-HSA-33715689 genes42 compounds

The Attenuation phase pathway (Reactome ID: R-HSA-3371568) involves 9 genes and is affected by 42 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREBBP EP300 FKBP4 HSP90AA1 HSP90AB1 HSPA1A HSPA1B HSPA8 PTGES3

Compounds Affecting Attenuation phase

#	Compound	Targets Hit	Studies
1	gedunin	—	54
2	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
3	Ergosterol	—	300
4	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
5	triolimus [Supplementary Concept]	—	33
6	monorden	—	8
7	celastrol	—	300
8	Novobiocin	—	300
9	caffeic acid	—	300
10	Masoprocol	—	300
11	Tetracycline	—	300
12	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
13	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
14	Quercetin	—	300
15	ag490	—	14
16	Hexachlorophene	—	300
17	Idarubicin	—	299
18	piceatannol	—	300
19	Nitroprusside	—	299
20	Adenosine Triphosphate	—	300
21	2-Chloroadenosine 2-Chloroadenosine.	—	300
22	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
23	Calcimycin	—	216
24	Calcitriol	—	300
25	Ciclopirox	—	88
26	Clotrimazole	—	296
27	cycloheximide	—	300
28	deguelin [Supplementary Concept]	—	151
29	Disulfiram	—	297
30	Indazoles	—	300
31	Miconazole	—	298
32	specioside	—	6
33	Wortmannin	—	300
34	Papaverine	—	299
35	Colchicine	—	300
36	Etazolate	—	66
37	Nocodazole Nocodazole is	—	215
38	plumbagin [Supplementary Concept]	—	300
39	egcg	—	300
40	11-hydroxypalmatine [Supplementary Concept]	—	238
41	Sirolimus	—	300
42	Everolimus	—	297

About the Attenuation phase Pathway

The Attenuation phase pathway is catalogued in Reactome (ID: R-HSA-3371568) and involves 9 genes. In the BiohacksAI corpus, 42 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREBBP, EP300, FKBP4, HSP90AA1, HSP90AB1.