What compounds affect the EPHB-mediated forward signaling pathway?

54 compounds in the BiohacksAI corpus have documented interactions with genes in the EPHB-mediated forward signaling pathway (Reactome ID: R-HSA-3928662). These compounds target 16 genes within this pathway.

What genes are in the EPHB-mediated forward signaling pathway?

The EPHB-mediated forward signaling pathway involves 16 genes. Key genes include: CDC42, CFL1, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FYN, GRIN1, GRIN2B.

EPHB-mediated forward signaling

REACTOME PATHWAY

Reactome: R-HSA-392866216 genes54 compounds

The EPHB-mediated forward signaling pathway (Reactome ID: R-HSA-3928662) involves 16 genes and is affected by 54 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDC42 CFL1 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 FYN GRIN1 GRIN2B LIMK1 LIMK2 LYN ROCK2 SRC YES1

Compounds Affecting EPHB-mediated forward signaling

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Crizotinib	—	298
3	Sorafenib	—	300
4	tyrphostin ag 1478	—	4
5	kenpaullone	—	8
6	alsterpaullone	—	12
7	Glutamic Acid	—	297
8	Glutamic Acid	—	300
9	Glycine	—	300
10	pentamidine	—	299
11	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
12	Dextrorphan Dextro form of levorphanol. It acts as	—	300
13	Levorphanol	—	297
14	cycloserine	—	298
15	Aspartic Acid	—	300
16	eliprodil	—	33
17	Memantine AMANTADINE derivative that has some dopaminergic effects. It has been proposed as	—	34
18	D-Aspartic Acid	—	29
19	Ethidium	—	300
20	Dextrothyroxine	—	134
21	Dizocilpine Maleate	—	300
22	Ibotenic Acid	—	300
23	Spermine	—	300
24	Quercetin	—	300
25	Axitinib	—	298
26	pictilisib	—	25
27	Afatinib	—	297
28	sp600125	—	117
29	Kynurenic Acid	—	300
30	Phenformin	—	300
31	Carvedilol	—	296
32	Kaempferols	—	300
33	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
34	Cladribine	—	297
35	Pioglitazone	—	297
36	Vemurafenib	—	298
37	Resveratrol	—	298
38	Adenosine Monophosphate Adenine nucleotide containing	—	300
39	monorden	—	8
40	Niclosamide	—	299
41	Rosmarinic Acid	—	300
42	Genistein	—	300
43	egcg	—	300
44	Acetic Acid Product of	—	300
45	hydroxyfasudil [Supplementary Concept]	—	11
46	Kinetin	—	300
47	Edaravone	—	298
48	Sertraline	—	1,000
49	Cinnarizine	—	299
50	Clofibrate	—	299

About the EPHB-mediated forward signaling Pathway

The EPHB-mediated forward signaling pathway is catalogued in Reactome (ID: R-HSA-3928662) and involves 16 genes. In the BiohacksAI corpus, 54 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDC42, CFL1, EPHB1, EPHB2, EPHB3.