What compounds affect the NCAM1 interactions pathway?

46 compounds in the BiohacksAI corpus have documented interactions with genes in the NCAM1 interactions pathway (Reactome ID: R-HSA-419037). These compounds target 7 genes within this pathway.

What genes are in the NCAM1 interactions pathway?

The NCAM1 interactions pathway involves 7 genes. Key genes include: CACNA1C, CACNA1D, CACNA1G, CACNA1H, CACNA1I, CACNA1S, PRNP.

NCAM1 interactions

REACTOME PATHWAY

Reactome: R-HSA-4190377 genes46 compounds

The NCAM1 interactions pathway (Reactome ID: R-HSA-419037) involves 7 genes and is affected by 46 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CACNA1C CACNA1D CACNA1G CACNA1H CACNA1I CACNA1S PRNP

Compounds Affecting NCAM1 interactions

#	Compound	Targets Hit	Studies
1	Astemizole Antihistamine drug now withdrawn from	—	280
2	Nitrendipine	—	299
3	Nisoldipine	—	297
4	Quinidine	—	298
5	Duloxetine Hydrochloride	—	993
6	Flunarizine Flunarizine is	—	299
7	Amlodipine	—	1,000
8	Hexachlorophene	—	300
9	Fluoxetine	—	1,000
10	Sertraline	—	1,000
11	Arachidonic Acid	—	245
12	Testosterone	—	299
13	Fluspirilene	—	74
14	cbd	—	298
15	Adapalene	—	296
16	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
17	cannabidiol	—	296
18	cgp37157	—	26
19	Clotrimazole	—	296
20	Crizotinib	—	298
21	Doripenem	—	298
22	Miconazole	—	298
23	Reserpine	—	297
24	Rimonabant	—	300
25	Troglitazone	—	299
26	Yohimbine	—	299
27	oxatomide [Supplementary Concept] structure;	—	128
28	Ethosuximide	—	297
29	Calcimycin	—	216
30	Danazol	—	298
31	Estriol	—	300
32	Ezetimibe	—	296
33	Loratadine	—	296
34	Metergoline	—	144
35	Nicardipine	—	94
36	Oxytetracycline	—	300
37	Ritonavir	—	298
38	Anisomycin	—	247
39	cycloheximide	—	300
40	torin 1	—	10
41	Tubercidin	—	300
42	urolithin b	—	49
43	Azacitidine	—	298
44	Azacitidine	—	300
45	Dasatinib	—	299
46	Promethazine	—	296

About the NCAM1 interactions Pathway

The NCAM1 interactions pathway is catalogued in Reactome (ID: R-HSA-419037) and involves 7 genes. In the BiohacksAI corpus, 46 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CACNA1C, CACNA1D, CACNA1G, CACNA1H, CACNA1I.