What compounds affect the Recycling pathway of L1 pathway?

44 compounds in the BiohacksAI corpus have documented interactions with genes in the Recycling pathway of L1 pathway (Reactome ID: R-HSA-437239). These compounds target 25 genes within this pathway.

What genes are in the Recycling pathway of L1 pathway?

The Recycling pathway of L1 pathway involves 25 genes. Key genes include: DPYSL2, MAPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA5, RPS6KA6, SRC, TUBA1A, TUBA1B.

Recycling pathway of L1

REACTOME PATHWAY

Reactome: R-HSA-43723925 genes44 compounds

The Recycling pathway of L1 pathway (Reactome ID: R-HSA-437239) involves 25 genes and is affected by 44 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

DPYSL2 MAPK1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 RPS6KA6 SRC TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B

Compounds Affecting Recycling pathway of L1

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Nocodazole Nocodazole is	—	215
3	Vincristine	—	299
4	Noscapine	—	300
5	Podophyllotoxin	—	14
6	Demecolcine	—	246
7	Maytansine	—	300
8	vinblastine sulfate	—	81
9	Vorinostat	—	299
10	sp600125	—	117
11	fisetin	—	78
12	Sorafenib	—	300
13	hydroxyfasudil [Supplementary Concept]	—	11
14	tyrphostin ag 1478	—	4
15	alsterpaullone	—	12
16	kenpaullone	—	8
17	Afatinib	—	297
18	pictilisib	—	25
19	plumbagin [Supplementary Concept]	—	300
20	pd98059	—	7
21	Clotrimazole	—	296
22	Progesterone	—	299
23	2-Chloroadenosine 2-Chloroadenosine.	—	300
24	Benzalkonium Compounds	—	299
25	Calcimycin	—	216
26	daph	—	2
27	Diphenhydramine	—	14
28	ha1004	—	4
29	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
30	Lithocholic Acid	—	300
31	Loratadine	—	296
32	trametinib	—	296
33	trequinsin hydrochloride	—	1
34	withaferin	—	300
35	Dasatinib	—	299
36	Resveratrol	—	298
37	Quercetin	—	300
38	Adenosine Monophosphate Adenine nucleotide containing	—	300
39	Crizotinib	—	298
40	monorden	—	8
41	Niclosamide	—	299
42	Kaempferols	—	300
43	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
44	Ergosterol	—	300

About the Recycling pathway of L1 Pathway

The Recycling pathway of L1 pathway is catalogued in Reactome (ID: R-HSA-437239) and involves 25 genes. In the BiohacksAI corpus, 44 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include DPYSL2, MAPK1, RPS6KA1, RPS6KA2, RPS6KA3.