What compounds affect the Uptake and actions of bacterial toxins pathway?

41 compounds in the BiohacksAI corpus have documented interactions with genes in the Uptake and actions of bacterial toxins pathway (Reactome ID: R-HSA-5339562). These compounds target 8 genes within this pathway.

What genes are in the Uptake and actions of bacterial toxins pathway?

The Uptake and actions of bacterial toxins pathway involves 8 genes. Key genes include: EEF2, FURIN, HSP90AA1, HSP90AB1, MAP2K1, MAP2K2, MAP2K3, MAP2K4.

Uptake and actions of bacterial toxins

REACTOME PATHWAY

Reactome: R-HSA-53395628 genes41 compounds

The Uptake and actions of bacterial toxins pathway (Reactome ID: R-HSA-5339562) involves 8 genes and is affected by 41 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

EEF2 FURIN HSP90AA1 HSP90AB1 MAP2K1 MAP2K2 MAP2K3 MAP2K4

Compounds Affecting Uptake and actions of bacterial toxins

#	Compound	Targets Hit	Studies
1	Vemurafenib	—	298
2	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
3	triolimus [Supplementary Concept]	—	33
4	monorden	—	8
5	gedunin	—	54
6	celastrol	—	300
7	Novobiocin	—	300
8	caffeic acid	—	300
9	Masoprocol	—	300
10	Tetracycline	—	300
11	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
12	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
13	Quercetin	—	300
14	ag490	—	14
15	cycloheximide	—	300
16	Idarubicin	—	299
17	piceatannol	—	300
18	Nitroprusside	—	299
19	trametinib	—	296
20	pd98059	—	7
21	Dasatinib	—	299
22	Axitinib	—	298
23	2-Chloroadenosine 2-Chloroadenosine.	—	300
24	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
25	Calcimycin	—	216
26	Calcitriol	—	300
27	Ciclopirox	—	88
28	Clotrimazole	—	296
29	deguelin [Supplementary Concept]	—	151
30	Disulfiram	—	297
31	Hexachlorophene	—	300
32	Indazoles	—	300
33	Miconazole	—	298
34	specioside	—	6
35	Wortmannin	—	300
36	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
37	Sorafenib	—	300
38	Genistein	—	300
39	Diminazene	—	300
40	silver sulfadiazine	—	299
41	Crizotinib	—	298

About the Uptake and actions of bacterial toxins Pathway

The Uptake and actions of bacterial toxins pathway is catalogued in Reactome (ID: R-HSA-5339562) and involves 8 genes. In the BiohacksAI corpus, 41 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EEF2, FURIN, HSP90AA1, HSP90AB1, MAP2K1.