What compounds affect the Phase 2 - plateau phase pathway?

40 compounds in the BiohacksAI corpus have documented interactions with genes in the Phase 2 - plateau phase pathway (Reactome ID: R-HSA-5576893). These compounds target 4 genes within this pathway.

What genes are in the Phase 2 - plateau phase pathway?

The Phase 2 - plateau phase pathway involves 4 genes. Key genes include: CACNA1C, CACNA2D2, KCNE1, KCNQ1.

Phase 2 - plateau phase

REACTOME PATHWAY

Reactome: R-HSA-55768934 genes40 compounds

The Phase 2 - plateau phase pathway (Reactome ID: R-HSA-5576893) involves 4 genes and is affected by 40 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CACNA1C CACNA2D2 KCNE1 KCNQ1

Compounds Affecting Phase 2 - plateau phase

#	Compound	Targets Hit	Studies
1	Duloxetine Hydrochloride	—	993
2	Nisoldipine	—	297
3	Clotrimazole	—	296
4	dihydrorotenone	—	13
5	Nitrendipine	—	299
6	Amlodipine	—	1,000
7	Fluoxetine	—	1,000
8	Sertraline	—	1,000
9	Quinidine	—	298
10	Arachidonic Acid	—	245
11	Testosterone	—	299
12	Fluspirilene	—	74
13	cbd	—	298
14	Adapalene	—	296
15	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
16	Astemizole Antihistamine drug now withdrawn from	—	280
17	cannabidiol	—	296
18	cgp37157	—	26
19	Crizotinib	—	298
20	Doripenem	—	298
21	Miconazole	—	298
22	Reserpine	—	297
23	Rimonabant	—	300
24	Troglitazone	—	299
25	Yohimbine	—	299
26	Oleic Acid	—	112
27	Calcimycin	—	216
28	Chlorhexidine	—	299
29	Hexachlorophene	—	300
30	Nortriptyline	—	28
31	Sphingosine	—	300
32	vinpocetine	—	299
33	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	—	287
34	Bisphenol A-Glycidyl Methacrylate	—	197
35	Calcitriol	—	300
36	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
37	Ethinyl Estradiol	—	300
38	Niflumic Acid	—	300
39	Thioridazine	—	35
40	Pregabalin	—	996

About the Phase 2 - plateau phase Pathway

The Phase 2 - plateau phase pathway is catalogued in Reactome (ID: R-HSA-5576893) and involves 4 genes. In the BiohacksAI corpus, 40 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CACNA1C, CACNA2D2, KCNE1, KCNQ1.