What genes are in the GLI3 is processed to GLI3R by the proteasome pathway?

The GLI3 is processed to GLI3R by the proteasome pathway involves 40 genes. Key genes include: ADRM1, CSNK1A1, CUL1, GLI3, GSK3B, PRKACA, PRKACB, PRKACG, PSMA1, PSMA2.

GLI3 is processed to GLI3R by the proteasome

Q: What compounds affect the GLI3 is processed to GLI3R by the proteasome pathway?

216 compounds in the BiohacksAI corpus have documented interactions with genes in the GLI3 is processed to GLI3R by the proteasome pathway (Reactome ID: R-HSA-5610785). These compounds target 40 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-561078540 genes216 compounds

The GLI3 is processed to GLI3R by the proteasome pathway (Reactome ID: R-HSA-5610785) involves 40 genes and is affected by 216 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CSNK1A1 CUL1 GLI3 GSK3B PRKACA PRKACB PRKACG PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11+10 more

Compounds Affecting GLI3 is processed to GLI3R by the proteasome

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	chrysin	—	300
5	egcg	—	300
6	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
7	ninhydrin	—	300
8	hydroxyfasudil [Supplementary Concept]	—	11
9	Genistein	—	300
10	Disulfiram	—	297
11	Kaempferols	—	300
12	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
13	candesartan cilexetil [Supplementary Concept]	—	300
14	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
15	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
16	Quercetin	—	300
17	Sorafenib	—	300
18	sp600125	—	117
19	Corticosterone	—	300
20	Estrone	—	300
21	Carbaryl	—	300
22	cycloheximide	—	300
23	Hexachlorophene	—	300
24	Pueraria	—	300
25	Dehydroepiandrosterone	—	300
26	Methylene Blue	—	200
27	Progesterone	—	299
28	Androstenedione	—	300
29	Chlorhexidine	—	299
30	Colchicine	—	300
31	Danazol	—	298
32	Dehydroepiandrosterone	—	300
33	Dihydrotestosterone	—	300
34	Estriol	—	300
35	Ethinyl Estradiol	—	300
36	Flutamide	—	298
37	Levonorgestrel	—	292
38	Norethindrone	—	300
39	Norgestrel	—	300
40	Piperonyl Butoxide	—	300
41	Rotenone	—	300
42	Testosterone Propionate	—	300
43	propyl gallate	—	261
44	Vitamin	—	295
45	Celecoxib	—	295
46	Dinoprostone	—	296
47	Finasteride	—	296
48	Leflunomide	—	297
49	Methyltestosterone	—	300
50	Oxymetholone	—	298

About the GLI3 is processed to GLI3R by the proteasome Pathway

The GLI3 is processed to GLI3R by the proteasome pathway is catalogued in Reactome (ID: R-HSA-5610785) and involves 40 genes. In the BiohacksAI corpus, 216 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CSNK1A1, CUL1, GLI3, GSK3B.