Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3

Q: What compounds affect the Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 pathway?

301 compounds in the BiohacksAI corpus have documented interactions with genes in the Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 pathway (Reactome ID: R-HSA-5625886). These compounds target 4 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-56258864 genes301 compounds

The Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 pathway (Reactome ID: R-HSA-5625886) involves 4 genes and is affected by 301 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AR KDM1A KDM4C PKN1

Compounds Affecting Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	triolimus [Supplementary Concept]	—	33
3	Dihydrotestosterone	—	300
4	Progesterone	—	299
5	Testosterone	—	299
6	Medroxyprogesterone Acetate	—	299
7	Spironolactone	—	298
8	Flutamide	—	298
9	Levonorgestrel	—	292
10	Norgestrel	—	300
11	Androstenedione	—	300
12	Ethinyl Estradiol	—	300
13	Testosterone Propionate	—	300
14	Prednisolone	—	1,000
15	Corticosterone	—	300
16	Budesonide	—	1,000
17	Lynestrenol	—	299
18	Methyltestosterone	—	300
19	Oxymetholone	—	298
20	Prednisone	—	298
21	Danazol	—	298
22	Estrone	—	300
23	Norethindrone	—	300
24	Ethisterone 17 alpha-Hydroxypregn-4-en-20-yn-3-one.	—	119
25	Ethynodiol Diacetate	—	300
26	Fluoxymesterone	—	278
27	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
28	cycloheximide	—	300
29	Ethidium	—	300
30	Ouabain	—	300
31	Hydrocortisone	—	299
32	Dehydroepiandrosterone	—	300
33	Betamethasone	—	299
34	Chlormadinone Acetate	—	300
35	Dactinomycin	—	297
36	Dehydroepiandrosterone	—	300
37	Fluorometholone	—	299
38	Hydrocortisone	—	298
39	Desoxycorticosterone	—	300
40	Digoxin	—	299
41	Disulfiram	—	297
42	Finasteride	—	296
43	Methylprednisolone	—	299
44	vinblastine sulfate	—	81
45	17-alpha-Hydroxyprogesterone	—	300
46	Azacitidine	—	298
47	Azacitidine	—	300
48	Canrenone	—	300
49	Chlorhexidine	—	299
50	Cortisone	—	299

About the Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Pathway

The Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 pathway is catalogued in Reactome (ID: R-HSA-5625886) and involves 4 genes. In the BiohacksAI corpus, 301 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AR, KDM1A, KDM4C, PKN1.