GLI proteins bind promoters of Hh responsive genes to promote transcription

Q: What compounds affect the GLI proteins bind promoters of Hh responsive genes to promote transcription pathway?

194 compounds in the BiohacksAI corpus have documented interactions with genes in the GLI proteins bind promoters of Hh responsive genes to promote transcription pathway (Reactome ID: R-HSA-5635851). These compounds target 1 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-56358511 genes194 compounds

The GLI proteins bind promoters of Hh responsive genes to promote transcription pathway (Reactome ID: R-HSA-5635851) involves 1 genes and is affected by 194 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GLI3

Compounds Affecting GLI proteins bind promoters of Hh responsive genes to promote transcription

#	Compound	Targets Hit	Studies
1	Corticosterone	—	300
2	Estrone	—	300
3	Carbaryl	—	300
4	cycloheximide	—	300
5	Hexachlorophene	—	300
6	Pueraria	—	300
7	Dehydroepiandrosterone	—	300
8	Genistein	—	300
9	Methylene Blue	—	200
10	Progesterone	—	299
11	Androstenedione	—	300
12	Chlorhexidine	—	299
13	Colchicine	—	300
14	Danazol	—	298
15	Dehydroepiandrosterone	—	300
16	Dihydrotestosterone	—	300
17	Estriol	—	300
18	Ethinyl Estradiol	—	300
19	Flutamide	—	298
20	Levonorgestrel	—	292
21	Norethindrone	—	300
22	Norgestrel	—	300
23	Piperonyl Butoxide	—	300
24	Reserpine	—	297
25	Rotenone	—	300
26	Testosterone Propionate	—	300
27	propyl gallate	—	261
28	Vitamin	—	295
29	Celecoxib	—	295
30	Dinoprostone	—	296
31	Disulfiram	—	297
32	Finasteride	—	296
33	Leflunomide	—	297
34	Methyltestosterone	—	300
35	Oxymetholone	—	298
36	Phenoxybenzamine	—	21
37	Podophyllotoxin	—	14
38	Budesonide	—	1,000
39	Kaempferols	—	300
40	Losartan	—	1,000
41	Resveratrol	—	298
42	Warfarin	—	1,000
43	Acetaldehyde	—	300
44	Aripiprazole	—	298
45	Astemizole Antihistamine drug now withdrawn from	—	280
46	Bufotenin	—	93
47	Buspirone	—	299
48	Carbamide Peroxide	—	299
49	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
50	Ciclopirox	—	88

About the GLI proteins bind promoters of Hh responsive genes to promote transcription Pathway

The GLI proteins bind promoters of Hh responsive genes to promote transcription pathway is catalogued in Reactome (ID: R-HSA-5635851) and involves 1 genes. In the BiohacksAI corpus, 194 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GLI3.