What compounds affect the Signaling by FGFR2 pathway?

55 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by FGFR2 pathway (Reactome ID: R-HSA-5654738). These compounds target 12 genes within this pathway.

What genes are in the Signaling by FGFR2 pathway?

The Signaling by FGFR2 pathway involves 12 genes. Key genes include: BRAF, FGF22, FGFR2, GRB2, HNRNPA1, MAPK1, MAPK3, MKNK1, PIK3R1, PPP2CA.

Signaling by FGFR2

REACTOME PATHWAY

Reactome: R-HSA-565473812 genes55 compounds

The Signaling by FGFR2 pathway (Reactome ID: R-HSA-5654738) involves 12 genes and is affected by 55 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BRAF FGF22 FGFR2 GRB2 HNRNPA1 MAPK1 MAPK3 MKNK1 PIK3R1 PPP2CA PTBP1 SRC

Compounds Affecting Signaling by FGFR2

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Quercetin	—	300
3	tyrphostin ag 1478	—	4
4	alsterpaullone	—	12
5	kenpaullone	—	8
6	Dasatinib	—	299
7	plumbagin [Supplementary Concept]	—	300
8	pd98059	—	7
9	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
10	trametinib	—	296
11	withaferin	—	300
12	Afatinib	—	297
13	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
14	Clotrimazole	—	296
15	sp600125	—	117
16	fisetin	—	78
17	Progesterone	—	299
18	2-Chloroadenosine 2-Chloroadenosine.	—	300
19	Benzalkonium Compounds	—	299
20	Calcimycin	—	216
21	daph	—	2
22	Diphenhydramine	—	14
23	ha1004	—	4
24	Lithocholic Acid	—	300
25	Loratadine	—	296
26	trequinsin hydrochloride	—	1
27	Resveratrol	—	298
28	Adenosine Monophosphate Adenine nucleotide containing	—	300
29	Crizotinib	—	298
30	monorden	—	8
31	Niclosamide	—	299
32	Azauridine	—	300
33	Carboxin	—	174
34	Digitoxin	—	300
35	Digoxin	—	299
36	Ethylenethiourea	—	300
37	Nadolol	—	297
38	Ouabain	—	300
39	streptonigrin	—	299
40	Sulfadiazine	—	298
41	Thioridazine	—	35
42	triflupromazine hydrochloride	—	12
43	pictilisib	—	25
44	Wortmannin	—	300
45	ly294002	—	11
46	alpelisib	—	227
47	Sirolimus	—	300
48	torin 1	—	10
49	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
50	hydroxyfasudil [Supplementary Concept]	—	11

About the Signaling by FGFR2 Pathway

The Signaling by FGFR2 pathway is catalogued in Reactome (ID: R-HSA-5654738) and involves 12 genes. In the BiohacksAI corpus, 55 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BRAF, FGF22, FGFR2, GRB2, HNRNPA1.