What compounds affect the Formation of Incision Complex in GG-NER pathway?

34 compounds in the BiohacksAI corpus have documented interactions with genes in the Formation of Incision Complex in GG-NER pathway (Reactome ID: R-HSA-5696395). These compounds target 6 genes within this pathway.

What genes are in the Formation of Incision Complex in GG-NER pathway?

The Formation of Incision Complex in GG-NER pathway involves 6 genes. Key genes include: CDK7, ERCC3, PARP1, RBX1, SUMO1, UBE2N.

Formation of Incision Complex in GG-NER

REACTOME PATHWAY

Reactome: R-HSA-56963956 genes34 compounds

The Formation of Incision Complex in GG-NER pathway (Reactome ID: R-HSA-5696395) involves 6 genes and is affected by 34 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK7 ERCC3 PARP1 RBX1 SUMO1 UBE2N

Compounds Affecting Formation of Incision Complex in GG-NER

#	Compound	Targets Hit	Studies
1	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
2	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
3	Bortezomib	—	300
4	Camptothecin	—	300
5	Clofarabine	—	298
6	Daunorubicin	—	298
7	Demecolcine	—	246
8	Epirubicin	—	300
9	Gemcitabine	—	300
10	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
11	Irinotecan	—	298
12	Nocodazole Nocodazole is	—	215
13	Podophyllotoxin	—	14
14	Teniposide	—	299
15	Thapsigargin	—	300
16	Trabectedin	—	297
17	naringin	—	300
18	Chlorhexidine	—	299
19	Perphenazine	—	297
20	Sphingosine	—	300
21	Resveratrol	—	298
22	Sertraline	—	1,000
23	Astemizole Antihistamine drug now withdrawn from	—	280
24	Canrenone	—	300
25	Thioridazine	—	35
26	Cefdinir	—	298
27	Cefixime	—	300
28	Hexachlorophene	—	300
29	Oxytetracycline	—	300
30	hydroxyfasudil [Supplementary Concept]	—	11
31	pictilisib	—	25
32	Sorafenib	—	300
33	ninhydrin	—	300
34	Tripterygium	—	300

About the Formation of Incision Complex in GG-NER Pathway

The Formation of Incision Complex in GG-NER pathway is catalogued in Reactome (ID: R-HSA-5696395) and involves 6 genes. In the BiohacksAI corpus, 34 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK7, ERCC3, PARP1, RBX1, SUMO1.