What genes are in the Switching of origins to a post-replicative state pathway?

The Switching of origins to a post-replicative state pathway involves 38 genes. Key genes include: ADRM1, CCNA1, CCNE2, CDK2, CUL1, GMNN, PSMA1, PSMA2, PSMA3, PSMA4.

Switching of origins to a post-replicative state

Q: What compounds affect the Switching of origins to a post-replicative state pathway?

78 compounds in the BiohacksAI corpus have documented interactions with genes in the Switching of origins to a post-replicative state pathway (Reactome ID: R-HSA-69052). These compounds target 38 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-6905238 genes78 compounds

The Switching of origins to a post-replicative state pathway (Reactome ID: R-HSA-69052) involves 38 genes and is affected by 78 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CCNA1 CCNE2 CDK2 CUL1 GMNN PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13+8 more

Compounds Affecting Switching of origins to a post-replicative state

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	kenpaullone	—	8
4	alsterpaullone	—	12
5	Disulfiram	—	297
6	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
7	sp600125	—	117
8	ninhydrin	—	300
9	Colchicine	—	300
10	Rotenone	—	300
11	2-Methoxyestradiol	—	300
12	Nocodazole Nocodazole is	—	215
13	Astemizole Antihistamine drug now withdrawn from	—	280
14	Metergoline	—	144
15	Podophyllotoxin	—	14
16	triflupromazine hydrochloride	—	12
17	Vorinostat	—	299
18	Calcimycin	—	216
19	Dasatinib	—	299
20	Digitoxin	—	300
21	Doxazosin	—	24
22	Ethinyl Estradiol	—	300
23	Hexachlorophene	—	300
24	Niclosamide	—	299
25	Duloxetine Hydrochloride	—	993
26	Oleic Acid	—	112
27	ag490	—	14
28	Azacitidine	—	298
29	Azacitidine	—	300
30	Calcifediol	—	300
31	Calcitriol	—	300
32	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
33	cinacalcet	—	298
34	Clotrimazole	—	296
35	Decitabine	—	298
36	Desogestrel	—	299
37	Dibucaine	—	299
38	Digoxin	—	299
39	Ethylestrenol	—	70
40	Ethylmaleimide	—	300
41	Feprazone	—	63
42	Flunarizine Flunarizine is	—	299
43	Flunarizine Flunarizine is	—	14
44	Fluspirilene	—	74
45	gedunin	—	54
46	Idazoxan	—	300
47	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
48	Loratadine	—	296
49	Methyldopa	—	297
50	Nisoldipine	—	297

About the Switching of origins to a post-replicative state Pathway

The Switching of origins to a post-replicative state pathway is catalogued in Reactome (ID: R-HSA-69052) and involves 38 genes. In the BiohacksAI corpus, 78 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CCNA1, CCNE2, CDK2, CUL1.