Cyclin A/B1/B2 associated events during G2/M transition

Q: What compounds affect the Cyclin A/B1/B2 associated events during G2/M transition pathway?

49 compounds in the BiohacksAI corpus have documented interactions with genes in the Cyclin A/B1/B2 associated events during G2/M transition pathway (Reactome ID: R-HSA-69273). These compounds target 15 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-6927315 genes49 compounds

The Cyclin A/B1/B2 associated events during G2/M transition pathway (Reactome ID: R-HSA-69273) involves 15 genes and is affected by 49 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCNA1 CCNB1 CCNB2 CDC25A CDC25B CDK1 CDK2 CDK7 FOXM1 PKMYT1 PLK1 PPME1 PPP2CA WEE1 XPO1

Compounds Affecting Cyclin A/B1/B2 associated events during G2/M transition

#	Compound	Targets Hit	Studies
1	kenpaullone	—	8
2	alsterpaullone	—	12
3	indirubin	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	chrysin	—	300
6	fisetin	—	78
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	sp600125	—	117
9	plumbagin [Supplementary Concept]	—	300
10	Quercetin	—	300
11	Sorafenib	—	300
12	Hexachlorophene	—	300
13	Vitamin K 3	—	300
14	Aurintricarboxylic Acid	—	184
15	Methylergonovine	—	14
16	Clofibrate	—	299
17	Fenofibrate	—	297
18	Sertraline	—	1,000
19	Cinnarizine	—	299
20	Clotrimazole	—	296
21	Rotenone	—	300
22	ly294002	—	11
23	Wortmannin	—	300
24	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
25	Oleic Acid	—	112
26	Simvastatin	—	1,000
27	cefaclor	—	299
28	Disulfiram	—	297
29	Lithocholic Acid	—	300
30	Nisoldipine	—	297
31	Oxyphenbutazone	—	300
32	Oxytetracycline	—	300
33	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
34	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
35	Nadolol	—	297
36	1-(5,8-dihydro-1,4-dihydroxy-5,8-dioxo-2-naphthyl)-4-methylpent-3-en-1-yl cinnamate [Supplementary Concept]	—	54
37	Oleanolic Acid	—	300
38	Fluocinonide	—	196
39	Pemoline	—	300
40	Sulfaguanidine	—	255
41	Ursodeoxycholic Acid	—	298
42	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
43	Anthralin	—	299
44	hydroxyfasudil [Supplementary Concept]	—	11
45	pictilisib	—	25
46	oridonin	—	300
47	Dasatinib	—	299
48	Okadaic Acid	—	300
49	Troglitazone	—	299

About the Cyclin A/B1/B2 associated events during G2/M transition Pathway

The Cyclin A/B1/B2 associated events during G2/M transition pathway is catalogued in Reactome (ID: R-HSA-69273) and involves 15 genes. In the BiohacksAI corpus, 49 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNA1, CCNB1, CCNB2, CDC25A, CDC25B.